Evaluation of simulative effect of adrenal steroids secretion by exposure to an extremely-low-frequency magnetic field.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870475
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental impact assessment; Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: The University of Tokushima
• Principal Investigator: Kitaoka Kazuyoshi 徳島大学, 教養教育院(仮称)設置準備室, 講師 (50432753)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 極低周波変動磁界 / コルチコステロン / アルドステロン / 副腎皮質

Outline of Final Research Achievements

Extremely low-frequency magnetic fields (ELF-MFs) are generated by power lines and household electrical devices.In the current study, we investigated the effect of ELF-MF exposure on the mouse adrenal cortex-derived Y-1 cell line and the human adrenal cortex-derived H295R cell line to clarify whether the ELF-MF stimulates adrenal steroidogenesis directly. ELF-MF exposure was found to significantly stimulate adrenal steroidogenesis in Y-1 cells, but the effect was weak in H295R cells. Our results suggest that ELF-MF exposure stimulates adrenal steroidogenesis via an increase in intracellular cAMP caused by the inhibition of phosphodiesterase activity in Y-1 cells.

Free Research Field

環境生理学