• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2016 Fiscal Year Final Research Report

Implication of lectin proteins for pathogensis of mental disorders.

Research Project

  • PDF
Project/Area Number 25870494
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Neurochemistry/Neuropharmacology
Research InstitutionKyushu University

Principal Investigator

Kajitani Kosuke  九州大学, 基幹教育院, 准教授 (10597272)

Research Collaborator Nakabeppu Yusaku  
Project Period (FY) 2013-04-01 – 2017-03-31
Keywordsガレクチン-1 / ガレクチン-3 / 統合失調症 / マウス / 海馬 / 介在神経
Outline of Final Research Achievements

Galectin (gal) is one of several well-studied proteins among the lectin families which are involved in various biological processes.The purpose of this project is to clarify the relationship between gal and mental disorders. In this study, we reported several new findings as follows: 1) 77% of gal-1-positive cells expressed somatostatin and 79% of gal-1-positive cells expressed GAD67 in the mouse hippocampus, 2)We counted the number of somatostatin-, parvalbumin-, and GAD67-positive cells in the hippocampi of both gal-1 knockout and wild-type mice. However, no significant differences were found, 3)The serum galectin-3 levels were significantly higher in patients with schizophrenia than they were in controls, 4), A significant positive correlation was found between the serum galectin-3 level and the positive symptoms score of the Brief Psychiatry Rating Scale.

Free Research Field

精神医学

URL: 

Published: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi