A study on the difference in properties between primary tumor cells and metastatic tumor cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 25870586
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science; Tumor biology
• Research Institution: Ibaraki Prefectural University of Health Science
• Principal Investigator: fujii yoshihiro 茨城県立医療大学, 保健医療学部, 助教 (20637540)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: がん原発巣・転移巣 / 放射線・薬剤感受性 / 遊走能・浸潤能

Outline of Final Research Achievements

In this study, we aimed to examine the optimal treatment method for each tumor cells by comparing the treatment effect of radiation and drugs of primary tumor cells and metastatic tumor cells.
As a result of comparing radiation susceptibility, drug sensitivity, migration ability and invasion ability between primary tumor cells and metastatic tumor cells, we could not observe the difference in sensitivity between X-rays and carbon ions which is heavy ions. In addition, it was found that for some drugs with anticancer effect, the effect was high only with cisplatin relative to metastatic tumor cells. There was no difference in migration / invasion ability between the two tumor cells.

Free Research Field

放射線生物学・放射線腫瘍学