2015 Fiscal Year Final Research Report
Clarification of the interaction between adipocyte and NKT cell and its application to metabolic syndrom
| Project/Area Number |
25870708
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
Experimental pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | NKT細胞 / 脂肪細胞 / 脂肪組織炎症 / メタボリックシンドローム |
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| Outline of Final Research Achievements |
To examine the interaction between adipocyte and NKT cell, NKT cells were cultured with differentiated 3T3-L1 adipocytes. We found that 3T3-L1 adipocytes expressed CD1d and presented the endogenous ligand to NKT cells. Activated NKT cells produced cytokines including IFN-g. Furthermore, IFN-g acted on adipocytes to induce more the expression of Cd1d1 and downregulated the expression of Adipoq. It was suggested that NKT cells have a pathogenic role to induce adipose tissue inflammation and insulin resistance by interacting with adipocytes.
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| Free Research Field |
免疫学
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