2014 Fiscal Year Final Research Report
How does miR-375 promote invasion in non-small-cell lung cancer?
| Project/Area Number |
25870716
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor biology
Respiratory organ internal medicine
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
YODA Satoshi 慶應義塾大学, 医学部, 共同研究員 (30468491)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 肺癌 / micro RNA |
|---|
| Outline of Final Research Achievements |
This study was performed concerning microRNAs which regulate the function of genes. We discovered that miR-375, one of microRNAs, regulates the gene named Claudin-1 in non-small cell lung cancer cells. We also reported that stronger expression of miR-375 was related to faster movement of cells and lung cancer patients with stronger expression of miR-375 had shorter survivals. It suggested that miR-375 is involved in metastasis of cancers.
|
| Free Research Field |
肺癌
|
