Novel Structural Motif for Imaging and Therapeutic Agent of Cancer Cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870836
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering; Chemical biology
• Research Institution: Komazawa University
• Principal Investigator: Okada Tomoko 駒澤大学, 医療健康科学部, 講師 (60409795)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Ikuro 東北工業大学, 工学部, 講師 (90516311)
• Research Collaborator: HONDA Masayuki ; ODAWARA Aoi
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: コラーゲンペプチド / 近赤外 / 集積 / 光熱治療 / がん細胞

Outline of Final Research Achievements

This study aimed to develop a novel structural motif of imaging and therapeutic agent for cancer cells. A novel agent was designed and synthesized by conjugation of collagen peptide and a near-infrared (NIR) responsive dye. The collagen peptide was incorporated for targeting collagen fibrils around cancer cells and the NIR dye was for triggering cytotoxicity in human glioma cells. The effective cytotoxicity was achieved by association of the collagen peptide with the collagen surrounding the cells. The results obtained in this study suggest a novel approach for delivering therapeutic imaging agent to targeting cells.

Free Research Field

生体機能関連化学