Elementary research for making use of the inhibitor of neutrophil elastase as periodontal disease treatment.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870843
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Periodontology; Pathobiological dentistry/Dental radiology
• Research Institution: Tsurumi University
• Principal Investigator: UJIIE Yuko 鶴見大学, 歯学部, 助教 (60588599)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 歯周病 / 好中球エラスターゼ / 破骨細胞 / 骨吸収

Outline of Final Research Achievements

Periodontal disease is extending inflammation to the periodontal tissue: gingival tissue, periodontal ligaments, alveolar bone, cementum. In this project, the inhibitor of neutrophil elastase (NE) is focused on its function that is one of the factor of suppressive alveolar bone loss. Previously, it has demonstrated the NE resolved the glycoprotein, existing a substrate among collagen fibers firstly. Then, degradation of periodontal ligament is progressing.
In this experiment, it is histologically examined that NE affects not only the degradation of periodontal ligament but also, alveolar bone which is adjacent to periodontal ligaments. For that reason, the effects of the NE investigated using the inhibitor of neutrophil elastase (Sivelestat). As result, the Sivelestat group recovered the number of osteoclasts which is surrounding of periodontal pocket compare with the group of without Sivelestat. Therefore, it is suggested that Sivelestat suppressive acts on alveolar bone loss.

Free Research Field

医歯薬学