A control of tooth movement by sympathetic nervous system and development of anti-drug for alveolar bone loss

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870861
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry; Functional basic dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: Sato Takuma 愛知学院大学, 歯学部, 講師 (80609868)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 歯の移動 / 交感神経 / 骨代謝 / β遮断薬 / 骨形成 / 骨吸収 / 骨量

Outline of Final Research Achievements

Recently, involvement of the sympathetic nervous system on bone metabolism has attracted attention. Osteoblastic and osteoclastic cells are presented β2-adrenergic receptor (β2-AR). In this study, the effects of butoxamine (BUT), a specific β2-AR antagonist on tooth movement were examined in spontaneously hypertensive rats (SHR) showing osteoporosis with hyperactivity of the sympathetic nervous system. The distance in the SHR control was longer than that in the Wistar-Kyoto rats (WKY) group, and no significant difference was found in the SHR treated with BUT compared with the WKY control. And BUT treatment resulted in a recovery of alveolar bone loss. These results suggest that the sympathetic nervous system is involved in tooth movement, and that BUT prevents alveolar bone loss by orthodontic tooth movement.

Free Research Field

歯科矯正学