2014 Fiscal Year Final Research Report
Leishmanicidal constituents from tropical plants and biochemical mechanism of the activity
| Project/Area Number |
25870985
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | リーシュマニア症 / 熱帯植物 / ミャンマー / 構造決定 / 抗リーシュマニア活性 |
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| Outline of Final Research Achievements |
We investigated the leishmanicidal constituents from tropical plants and attempted to build a new screening system to elucidate the biochemical mechanism of the leishmanicidal activity. Several extracts from the plants belonging to Caricaceae, Verbenaceae, and Zingiberaceae, were found to inhibit the activity in the first screening. Twenty-eight compounds were isolated, and their activity as well as cytotoxicity against RAW 264.7 was examined. Additionally, the active compounds were subjected to an ATP-bioluminescence assay for measuring intracellular ATP level of promastigotes.
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| Free Research Field |
天然物化学，生薬学，構造解析学
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