2014 Fiscal Year Final Research Report
A screen for novel TGFb crosstalk modulator
| Project/Area Number |
25871177
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
Tumor biology
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
INUI Masafumi 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 室長 (20643498)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | TGFβ / クロストーク |
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| Outline of Final Research Achievements |
In this study I performed a functional screening for novel TGFβ signaling modulators of which the activity to regulate TGFβ signaling depends on the input of other signaling pathways such as Wnt, BMP and FGF/MAPK. Using high-throughput gene expression system, TGFβ responsive luciferase reporter and mammalian cell line, I have screened more than 16000 factors and identified several novel TGFβ signaling modulator candidates of which activities change (promoted or inhibited) upon other signaling stimuli. Those factors could be the foci of the crosstalk and further analysis will reveal novel interaction between TGFβ signaling and other signaling pathways
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| Free Research Field |
細胞生物学
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