Detection of circulating tumor stem cells by use of a cell microarray chip

2014 Fiscal Year Final Research Report

• Project/Area Number: 25871189
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nanobioscience; Tumor diagnostics
• Research Institution: The University of Tokushima (2014); National Institute of Advanced Industrial Science and Technology (2013)
• Principal Investigator: ABE Kaori 徳島大学, 大学病院, 特任助教 (60511326)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: マイクロチップ / がん幹細胞 / 単一細胞解析

Outline of Final Research Achievements

Cancer stem cells play an important role in cancer metastases. Recently, it has been reported that cancer stem cells exist not only in tumor tissue but also in peripheral blood. However, the conventional systems fail to detect circulating tumor stem cells (CTSC) because the rate of CTSC in peripheral blood is very low. In a previous study of ours, we developed a cell microarray chip with 20,944 microchambers (105 μm width and 50 μm depth). We could analyze 2,000,000 leukocytes on a cell microarray chip. In the present study, we developed a sensitive, simple, and accurate system to detect CTSC using a cell microarray chip.

Free Research Field

マイクロチップ基板でのバイオマーカー解析