Analysis of antigen presentation mediated with constitutively active autophagy that induced by K-ras mutation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25871227
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor therapeutics; Immunology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: Demachi-Okamura Ayako 愛知県がんセンター(研究所), 腫瘍免疫学部, 主任研究員 (10546948)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: CTL / がん / 免疫 / オートファジー / 膵臓癌

Outline of Final Research Achievements

The association of K-ras mutation and constitutively active autophagy was investigated. To this end, immortalized normal epithelial cell line was transduced with mutated K-ras gene (G12V). The mutated K-ras-expressing cells had constitutively active autophagosomes. As a results, the cells produced autophagosome-dependent epitopes. These data suggest that the pancreatic cancerous cells having mutated K-ras gene possess tumor-specific antigen presenting machinery.

Free Research Field

腫瘍免疫学