Identification and elucidation of functional relationship between neuronal exosomal ncRNA and Lewy body dementia

2014 Fiscal Year Final Research Report

• Project/Area Number: 25890012
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Osaka University
• Principal Investigator: KAWAHARA Hironori 大阪大学, 免疫学フロンティア研究センター, 特任研究員 (00424177)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: exosome / α-synuclein / IP3 / ncRNA / 脳神経疾患

Outline of Final Research Achievements

Exosome is not only signal small vesicle which is utilized as cell-cell communication in various cells but also in neuronal cells. However, it remains unclear that the mechanisms by which neuronal exosomes are propagated within neuronal cells, particularly under IP3-stimulation. Novel lncRNAs (long non-coding RNAs) and proteins which were incorporated into IP3-stimulated exosomes were identified in mouse primary neurons. α-synuclein was efficiently incorporated into exosomes by Rpn1, and then efficiently transferred to glia cells via exosomes.

Free Research Field

神経科学一般