2014 Fiscal Year Final Research Report
Development of a novel treatment for infected wound based on photo-irradiation of polyphenols
| Project/Area Number |
25893019
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | ポリフェノール / 過酸化水素光分解殺菌 / ヒドロキシルラジカル / プロアントシアニジン |
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| Outline of Final Research Achievements |
In the present study, an effect of proanthocyanidin (PA), one of polyphenols, on proliferation of human gingival fibroblast was investigated. It was found that PA accelerated the cell proliferation depending on the concentration. Under the harsh conditions, such as exposure to osmotic stress, starvation stress and serum deprivation stress, the short-time pretreatment with polyphenols exerted cytoprotective effect by means of suppression of yield of reactive oxygen species produced in the cells. These findings suggest that PA which exerts not only facilitatory effect of cell proliferation but also cytoprotective effect may be applied to treatment for infected wound.
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| Free Research Field |
歯科補綴
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