2014 Fiscal Year Final Research Report
The role of polycomb complex on the clonal evolution in myelodysplastic syndrome
| Project/Area Number |
25893049
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | 骨髄異形成症候群 / ポリコーム |
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| Outline of Final Research Achievements |
Myelodysplastic syndrome (MDS) has a varied clinical course, with some patients remaining asymptomatic with mild cytopenia for a long time, while others show progressive leukemia a short time after the diagnosis. In the present study, we analyzed whether epigenetic alternation could contribute to the disease progression of MDS. It is suggested that alteration of oncogene expression is regulated by histone modification. This study suggested a new role of epigenetic alternation in the disease progression of MDS and possibilities of these processes as new targets of novel molecular therapy.
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| Free Research Field |
造血器疾患
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