The roles of cyclic adenosine monophosphate (cAMP) in suppressive functions of regulatory T cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893115
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Osaka University
• Principal Investigator: MIKAMI Norihisa 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (20710388)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 制御性T細胞 / cAMP

Outline of Final Research Achievements

As results of the analysis of the effect on regulatory T cells of cAMP signaling, we demonstrated that it contributes to the Helios stability and IL-2 expression in regulatory T cells. Moreover, cAMP signal is induced to effector T cells by regulatory T cells, whereby it was shown that IL-2 production from effector T cells is also inhibited. Furthermore, it becomes clear that dendritic cells are also affected by regulatory T cells occurs, and the production of inflammatory cytokines such as IL-12 were also decreased by induced cAMP signaling.

Free Research Field

免疫学