Establishment of the mechanism analysis method of bioactive compounds based on the chemical genetics

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893142
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Natural medicines
• Research Institution: Hiroshima University
• Principal Investigator: YAMANO YOSHI 広島大学, 医歯薬保健学研究院(薬), 助教 (70650597)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 線虫 / C. elegans / 抗寄生虫 / 生物活性物質

Outline of Final Research Achievements

we examined antiparasitic substance from plant extracts and tried to establish a new method for elucidating the action mechanism of active compounds. In this experiment, we used C. elegans as a model of parasite and isolated 14 compounds from 3 kinds of plants. Then the action mechanism of isolated compounds examined by using deletion mutant and drug-resistant mutant strain. The result showed that 4-hydroxyphenylpyruvate dioxygenase (HPD-1) is candidate of target molecule of proctorione C.

Free Research Field

天然物化学