Expansion into the establishment of jaw cleft treatment with bone regeneration by use of mesenchymal stem cells with excellent ability to induce blood vessel

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893148
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: SUMI Keisuke 広島大学, 医歯薬保健学研究院(歯), 助教 (00707078)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 骨再生 / 未分化間葉系幹細胞 / 矯正歯科

Outline of Final Research Achievements

The aim of this study is bone regeneration of Jaw cleft of patients with cleft lip and palate (CLP) by use of mesenchymal stem cells (MSCs), so we examined the effects of MSCs on angiogenesis. From the results, it was suggested VEGF expression of MSCs was increased as compared with which of osteoblast differentiation, the angiogenesis of endothelial cells was promoted by coculture with MSCs. Additionally, vascularization of the transplanted area initial blood flow was increased and enhanced by transplantation of MSCs in vivo. So it was suggested that applications of this method may be available as a new therapeutic tool for CLP.

Free Research Field

骨再生