2014 Fiscal Year Final Research Report
To generate and analyze new Parkinson's disease mice model with increased oxidative stress
| Project/Area Number |
25893163
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Takahiko 千葉大学, 医学部, 准教授 (40301791)
KIRA Jun-ichi 九州大学, 医学部, 教授 (40183305)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | パーキンソン病 / 酸化ストレス |
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| Outline of Final Research Achievements |
To investigate the role of mitochondrial dysfunction and oxidative stress in the dopaminergic neuronal death in PD(Parkinson's disease), we try to generate the dopaminergic neuron specific conditional knockout mice in which Superoxide dismutase-2(SOD2) is conditionally knocked out in dopaminergic neuron. We have established TH- CreER Tg mice and SOD2 (Superoxide dismutase-2) flox/flox mice colonies. To investigate the role of DJ-1, a responsible gene for PD,in the dopaminergic neuronal death, we will breed DJ-1 KO mice with dopaminergic neuron specific SOD2 conditional knockout mice and analyze.
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| Free Research Field |
神経内科学
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