Role of anti-apoptotic Bcl-xL in osteoblasts

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893182
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Nagasaki University
• Principal Investigator: KAWAI Yosuke 長崎大学, 病院(歯学系), 助教 (50423629)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 骨芽細胞 / アポトーシス / BclxL

Outline of Final Research Achievements

In the present study, we generated conditional knockout mice with osteoblasts that express anti-apoptotic BCL-XL by using 2.3kb Col1a1 promoter Cre transgenic mice. In BCL-XL conditional knockout mice, apoptosis was increased in osteoblasts. Expression of BCL-XL in osteoblasts affected osteoclastogenesis. As a results, bone volume was decreased at 10 weeks of age because osteoclast formation was increased. These results show that BCL-XL may become the target for the osteoporosis treatment in the future.

Free Research Field

外科系歯学