Pathological mechanism of intracranial dolichoectasia -to resolve the dilemma in antithrombotic treatment

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893185
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: Kumamoto University
• Principal Investigator: NAKAJIMA Makoto 熊本大学, 大学院生命科学研究部, 助教 (90530147)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 脳神経疾患 / 神経科学 / 臨床 / 分析科学病理学 / 国際情報交換 / 国際研究者交流

Outline of Final Research Achievements

We investigated prevalence, background characteristics, and prognosis of patients with vertebrobasilar ectasia in patients with subcortical small strokes using the dataset of the international multicenter trial of SPS3. No associations were found between vertebrobasilar ectasia and incidence of stroke or major bleeding, however, mortality was higher in patients with vertebrobasilar ectasia than others. We also investigated factors associated with vertebrobasilar ectasia in patients with acute ischemic stroke in our country. Prevalence of vertebrobasilar ectasia was lower than SPS3 dataset and small vessel occlusion was more frequently observed than other stroke subtype as previously reported. We conducted further analyses in the relationship between signal intensity ratio of each intracranial vessel and outcome, however found no significant association.

Free Research Field

病態検査学