Establishment of the standards for suspected drugs under drug-induced liver injury by clinical and basic study

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893276
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Kobe Gakuin University
• Principal Investigator: IKEMURA Mai 神戸学院大学, 薬学部, 講師 (60709278)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 薬剤性肝障害 / ALT / 臨床 / フェニトイン

Outline of Final Research Achievements

Drug-induced liver injury (DILI) is occasionally occurred in clinical settings. It is difficult to decide when to discontinue the suspected drugs with consideration for both the symptoms of DILI and therapeutic effects by the drugs. In this study, I evaluated the hepatic enzyme level and liver function under DILI by phenytoin, antiepileptic drug, using patients' medical records and animal models. Investigation of medical records revealed that ALT levels were fallen immediately after the discontinuation of the medication in the most of study patients, but, in some cases, it was required a lot of time to return to normal level. Experiments using murine models investigated that liver function was different in spite of the same ALT level. These results suggest that it is needed to establish the standards for a discontinuation of the suspected drugs with consideration for liver function under DILI.

Free Research Field

医療薬学