Mechanism analysis of lasting of AIDS virus control with SIV controllers.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893294
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: NOMURA Takushi 国立感染症研究所, その他部局等, 研究員 (80711001)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: エイズウイルス / サルエイズモデル / 新規CTLエピトープ決定 / CTL逃避変異選択 / 複製抑制維持 / 宿主免疫応答 / 免疫動態解析

Outline of Final Research Achievements

CTL epitopes Nef9-19, Nef89-97 and Nef193-203 restricted by MHC-I haplotype 90-120-Ia were newly identified by using SIV infected Burmese rhesus macaque AIDS model in this research. A group of macaques that control SIV replication for more than 2 years showed multiple nef mutations including those escaping from Nef9-19 and Nef89-97 epitope-specific CTL responses at 2 years post SIV challenge. However, almost no mutation was observed in Nef193-203 epitopes, suggesting that Nef193-203 epitope-specific CTL responses may maintain efficacy of SIV suppression in this group. Moreover, Nef193-203 specific CTL responses were detected in almost all animals at 2 years post challenge. Thus, Nef193-203 specific CTL responses may contribute to sustained viremia control in SIV controllers.

Free Research Field

感染病態学