Multiple Omics Analysis to Understand the Species Differences in Chemical-intracellular Receptor Signaling Disruption

2018 Fiscal Year Annual Research Report

• Project/Area Number: 26220103
• Research Institution: Ehime University
• Principal Investigator: 岩田 久人 愛媛大学, 沿岸環境科学研究センター, 教授 (10271652)
• Co-Investigator(Kenkyū-buntansha): 野見山 桂 愛媛大学, 沿岸環境科学研究センター, 准教授 (30512686) ; 阿草 哲郎 熊本県立大学, 環境共生学部, 准教授 (50403853) ; 田辺 信介 愛媛大学, 沿岸環境科学研究センター, 特別栄誉教授 (60116952) ; 中田 晴彦 熊本大学, 大学院先端科学研究部(理), 准教授 (60311875) ; 久保田 彰 帯広畜産大学, 畜産学部, 准教授 (60432811) ; 国末 達也 愛媛大学, 沿岸環境科学研究センター, 教授 (90380287)
• Project Period (FY): 2014-05-30 – 2019-03-31
• Keywords: 感受性 / 細胞内受容体 / オミックス / プロテオーム / トランスクリプトーム

Outline of Annual Research Achievements

１）道路粉塵中マイクロプラスチック (MP) 粒子に含まれる添加物質を分析し、路面標示と同種の紫外線吸収剤・リン系難燃剤・フタル酸系可塑剤等を検出した。甲状腺ホルモンシグナル伝達系撹乱の指標となる血中遊離型甲状腺ホルモン（THs）の高精度機器分析法について検討し、多様な生物種に適用可能な分析法の確立に成功した。ネコを対象に、臭素化ジフェニルエーテルBDE209の長期曝露試験を実施し、ネコのBDE209の代謝過程は脱臭素が主体であることがわかった。
２）ゼブラフィッシュを用いて多様なビスフェノール類（BPs）の抗エストロゲン作用を評価した。その結果、部分アゴニスト作用を示したBPsは、エストラジオール（E2）誘導性のCYP19A1b遺伝子の発現を濃度依存的に抑制した。部分アゴニスト作用を示したBPsの抗エストロゲン作用は、少なくとも一部は、エストロゲン受容体とのin silicoドッキングシミュレーションによって予測できることが明らかとなった。
３）ニワトリ胚へトリクロサンを暴露し、肝臓プロテームを解析した結果、トリクロサンは脂質やエネルギー代謝関連タンパク質の発現に影響することがわかった。この結果はトランスクリプトーム解析の結果と一致した。
４）PCBs曝露したネコ肝臓のトランスクリプトームを解析した結果、炎症・感染症・脂肪酸代謝に関連する遺伝子の変化が認められ、免疫系および脂質代謝系への影響が示唆された。バルト海産サケの肝臓のトランスクリプトーム・プロテオームを解析し、両プロファイルと残留性有機汚染物質濃度に強い相関関係を見出した。
５）In vitroレポーター遺伝子アッセイ系を用いて臭化ジフェニルエーテル（PBDEs）のバイカルアザラシペルオキシソーム増殖因子活性化受容体 αの転写活性化能を調べた。一部のPBDEsの転写活性化能は、有機フッ素系化合物より高いことがわかった。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Remarks

掲載論文紹介：EurekAlert!: https://www.eurekalert.org/pub_releases/2019-03/eu-bao032719.php
岩田久人 Research map: https://researchmap.jp/read0045620

Research Products

• [Int'l Joint Research] Kyung Hee University(韓国)
  • Country Name: KOREA (REP. OF KOREA)
  • Counterpart Institution: Kyung Hee University
• [Int'l Joint Research] New York State Dept. of Health(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: New York State Dept. of Health
• [Int'l Joint Research] Russian Academy of Sciences(ロシア連邦)
  • Country Name: RUSSIA FEDERATION
  • Counterpart Institution: Russian Academy of Sciences
• [Int'l Joint Research] Vietnam National University(ベトナム)
  • Country Name: VIET NAM
  • Counterpart Institution: Vietnam National University
• [Int'l Joint Research] University of the Philippines Los Banos(フィリピン)
  • Country Name: PHILIPPINES
  • Counterpart Institution: University of the Philippines Los Banos
• [Journal Article] In Vitro and In Silico Evaluations of Binding Affinities of Perfluoroalkyl Substances to Baikal Seal and Human Peroxisome Proliferator-Activated Receptor α (2019)
  • Author(s): Hiroshi Ishibashi, Masashi Hirano, Eun-Young Kim, and Hisato Iwata
  • Journal Title: Environmental Science & Technology Volume: 53 Pages: 2181-2188
  • DOI: 10.1021/acs.est.8b07273
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The aryl hydrocarbon receptor 2 potentially mediates cytochrome P450 1A induction in the jungle crow (Corvus macrorhynchos) (2019)
  • Author(s): Eun-Young Kim, Naomi Inoue, Dong-Hee Koh, Hisato Iwata
  • Journal Title: Ecotoxicology and Environmental Safety Volume: 171 Pages: 99-111
  • DOI: https://doi.org/10.1016/j.ecoenv.2018.12.037
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Seasonal variation of atmospheric organochlorine pesticides and polybrominated diphenyl ethers in Parangipettai, Tamil Nadu, India: Implication for atmospheric transport (2019)
  • Author(s): Paromita Chakraborty, Gan Zhang, Jun Li, Pitchai Sampathkumar, Thangavel Balasubramanian, Kandasamy Kathiresan, Shin Takahashi, Annamalai Subramanian, Shinsuke Tanabe, Kevin C. Jones
  • Journal Title: Science of the Total Environment Volume: 649 Pages: 1653-1660
  • DOI: 10.1016/j.scitotenv.2018.07.414
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Occurrence of benzotriazole ultraviolet stabilizers (BUVSs) in human breast milk from three Asian countries (2019)
  • Author(s): Joon-Woo Kim, Kwang-Hyeon Chang, Maricar Prudente, Pham Hung Viet, Shin Takahashi, Shinsuke Tanabe, Tatsuya Kunisue, Tomohiko Isobe
  • Journal Title: Science of the Total Environment Volume: 655 Pages: 1081-1088
  • DOI: 10.1016/j.scitotenv.2018.11.298
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of a data-processing method for target and non-target screening using comprehensive two-dimensional gas chromatography coupled with high-resolution time-of-flight mass spectrometry for environmental samples (2019)
  • Author(s): Teruyo Ieda, Shunji Hashimoto, Tomohiko Isobe, Tatsuya Kunisue, Shinsuke Tanabe
  • Journal Title: Talanta Volume: 194 Pages: 461-468
  • DOI: 10.1016/j.talanta.2018.10.050
  • Peer Reviewed
• [Journal Article] Development of a novel scheme for rapid screening for environmental micropollutants in emergency situations (REPE) and its application for comprehensive analysis of tsunami sediments deposited by the great east Japan earthquake. (2019)
  • Author(s): Yuki Matsuo, Takashi Miyawaki, Kiwao Kadokami, Kunihiko Nakai, Nozomi Tatsuta, Haruhiko Nakata, Toru Matsumura, Hiromitsu Nagasaka, Masafumi Nakamura, Katsuhisa Sato, Kenichi Tobo, Risa Kakimoto, Takashi Someya, Daisuke Ueno
  • Journal Title: Chemosphere Volume: 224 Pages: 39-47
  • DOI: 10.1016/j.chemosphere.2019.02.078
  • Peer Reviewed
• [Journal Article] 下水マーカーを指標にした熊本地震による下水管破損と地下水汚染の実態把握と施策提言に関する研究 (2019)
  • Author(s): 中田晴彦
  • Journal Title: 下水道協会誌 Volume: 56 Pages: 99-100
• [Journal Article] プラスチック汚染 －市販製品に含まれるマイクロプラスチックについて (2019)
  • Author(s): 中田晴彦・北原健一
  • Journal Title: 科学 Volume: 89 Pages: 52-53
• [Journal Article] Protecting the environment from psychoactive drugs: Problems for regulators illustrated by the possible effects of tramadol on fish behaviour (2019)
  • Author(s): Rumi Tanoue, Luigi Margiotta-Casaluci, Belinda Huerta, Tamsin J. Runnalls, Akifumi Eguchi, Kei Nomiyama, Tatsuya Kunisue, Shinsuke Tanabe, John P. Sumpter
  • Journal Title: Science of The Total Environment Volume: 664 Pages: 915-926
  • DOI: doi.org/10.1016/j.scitotenv.2019.02.090
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In ovo exposure to triclosan alters the hepatic proteome in chicken embryos (2018)
  • Author(s): Guo, J., Nguyen, T. H., Ito, S., Yamamoto, K., Kanerva, M., Iwata, H.
  • Journal Title: Ecotoxicology and Environmental Safety Volume: 165 Pages: 495-504
  • DOI: https://doi.org/10.1016/j.ecoenv.2018.09.043
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of 4-Hydroxy-2,3,3′,4′,5-Pentachlorobiphenyl (4-OH-CB107) on Liver Transcriptome in Rats: Implication in the Disruption of Circadian Rhythm and Fatty Acid Metabolism (2018)
  • Author(s): Ochiai, M., Iida, M., Agusa, T., Takaguchi, K., Fujii, S., Nomiyama, K., Iwata, H.
  • Journal Title: Toxicological Sciences Volume: 165 Pages: 118-130
  • DOI: https://doi.org/10.1093/toxsci/kfy123
  • Peer Reviewed
• [Journal Article] Effects on the hepatic transcriptome of chicken embryos in ovo exposed to phenobarbital (2018)
  • Author(s): Guo, J., Ito, S., Nguyen, T. H., Yamamoto, K., Iwata H.
  • Journal Title: Ecotoxicology and Environmental Safety Volume: 160 Pages: 94-103
  • DOI: https://doi.org/10.1016/j.ecoenv.2018.05.033
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos (2018)
  • Author(s): Guo, J., Ito, S., Nguyen, T. H., Yamamoto, K., Tanoue, R., Kunisue, T., Iwata H.
  • Journal Title: Toxicology and Applied Pharmacology Volume: 347 Pages: 23-32
  • DOI: https:// doi.org/10.1016/j.taap.2018.03.026.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Soil Pollution by Chlorobenzenes and Polychlorinated Biphenyls from an Electronic Waste Recycling Area in Northern Vietnam (2018)
  • Author(s): Nishimura, C., Suzuki, G., Matsukami, H., Agusa, T., Takaoka, M., Takahashi, S., Tue, N. M., Viet, P. H., Tanabe, S., Takigami, H., Fujimori, T.
  • Journal Title: International Journal of Environment and Pollution Volume: 63 Pages: 283-297
  • DOI: 10.1504/IJEP.2018.097863
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exposure assessment of heavy metals in an e-waste processing area in northern Vietnam (2018)
  • Author(s): Tomoto Oguri, Go Suzuki, Hidenori Matsukami, Natsuyo Uchida, Nguyen Minh Tue, Le Huu Tuyen, Pham Hung Viet, Shin Takahashi, Shinsuke Tanabe, Hidetaka Takigami
  • Journal Title: Science of the Total Environment Volume: 621 Pages: 1115-1123
  • DOI: 10.1016/j.scitotenv.2017.10.115
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hazardous metals emissions from e-waste-processing sites in a village in northern Vietnam (2018)
  • Author(s): Natsuyo Uchida, Hidenori Matsukami, Masayuki Someya, Nguyen Minh Tue, Le Huu Tuyen, Pham Hung Viet, Shin Takahashi, Shinsuke Tanabe, Go Suzuki
  • Journal Title: Emerging Contaminants Volume: 4 Pages: 11-21
  • DOI: 10.1016/j.emcon.2018.10.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Trace element concentrations in the small Indian mongoose (Herpestes auropunctatus) from Hawaii, USA (2018)
  • Author(s): Sawako Horai, Yusuke Nakashima, Kanae Nawada, Izumi Watanabe, Tatsuya Kunisue, Shintaro Abe, Fumio Yamada, Robert Sugihara
  • Journal Title: Ecological Indicators Volume: 91 Pages: 92-104
  • DOI: 10.1016/j.ecolind.2018.03.058
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The evolution of UDP-glycosyl/glucuronosyltransferase 1E (UGT1E) genes in bird lineages is linked to feeding habits but UGT2 genes is not. (2018)
  • Author(s): Yusuke K. Kawai, Yoshinori Ikenaka, Mayumi Ishizuka, Akira Kubota
  • Journal Title: PLoS One Volume: 13 Pages: e0205266
  • DOI: https://doi.org/10.1371/journal.pone.0205266
  • Peer Reviewed / Open Access
• [Journal Article] Determination of free thyroid hormones in animal serum/plasma using ultrafiltration in combination with ultra-fast liquid chromatography-tandem mass spectrometry (2018)
  • Author(s): Rumi Tanoue, Imari Kume, Yasuo Yamamoto, Kohki Takaguchi, Kei Nomiyama, Shinsuke Tanabe, Tatsuya Kunisue
  • Journal Title: Journal of Chromatography A Volume: 1539 Pages: 30-40
  • DOI: doi: 10.1016/j.chroma.2018.01.044.
  • Peer Reviewed
• [Journal Article] Alterations in urinary metabolic profiles due to lead exposure from a lead-acid battery recycling site (2018)
  • Author(s): Eguchi Akifumi, Nomiyama Kei, Sakurai Kenichi, Pham Thi Kim Trang, Pham Hung Viet, Shin Takahashi, Hisato Iwata, Shinsuke Tanabe, Emiko Todaka, Chisato Mori
  • Journal Title: Environmental Pollution Volume: 242 Pages: 98-105
  • DOI: doi.org/10.1016/j.envpol.2018.06.071
  • Peer Reviewed / Int'l Joint Research
• [Presentation] In vivo measurement and in silico prediction of estrogen-like potency of bisphenol A and its analogues in zebrafish (2019)
  • Author(s): Akira Kubota, Jae Seung Lee, Yumi Wakayama, Michiko Nakamura, Yuka Yoshinouchi, Hisato Iwata, Masashi Hirano, Haruhiko Nakata, Yusuke Kawai
  • Organizer: SOT 58th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] In vivo measurement and in silico prediction of estrogenic and anti-estrogenic potency of bisphenol A and its analogues in zebrafish (2019)
  • Author(s): Akira Kubota, Jae Seung Lee, Yumi Wakayama, Michiko Nakamura, Yuka Yoshinouchi, Hisato Iwata, Masashi Hirano, Yusuke Kawai
  • Organizer: International Chemical Hazard Symposium in Hokkaido
  • Int'l Joint Research / Invited
• [Presentation] 陸域におけるマイクロプラスチックの発生源検証 (2019)
  • Author(s): 北原健一・中田晴彦
  • Organizer: 第52回日本水環境学会年会
• [Presentation] 難分解性下水マーカーによる地下インフラのリスク管理に関する基礎研究―大規模災害を見据えて― (2019)
  • Author(s): 石井絵理・中田晴彦
  • Organizer: 第52回日本水環境学会年会
• [Presentation] Implication of obesogenic effects of prenatal bisphenol A exposure on rat offspring by multi-omics analysis (2018)
  • Author(s): Hoa Thanh Nguyen, Kimika Yamamoto, Midori Iida, Tetsuro Agusa, Mari Ochiai, Lingyun Li, Kurunthachalam Kannan, Eun-Young Kim, Hisato Iwata
  • Organizer: 環境ホルモン学会 第21回研究発表会
• [Presentation] Effects of exposure to tris(2-chloroethyl)phosphate (TCEP) on chicken embryos: in situ observation in a shell-less incubation system (2018)
  • Author(s): Kazuki Kanda, Shohei lto, Dong-Hee Koh, Eun-Young Kim, Hisato Iwata
  • Organizer: 環境ホルモン学会 第21回研究発表会
• [Presentation] In situ observation of chicken embryos treated with tris(2-chloroethyl) phosphate (TCEP) in the shell-less incubation system (2018)
  • Author(s): Kazuki Kanda, Shohei Ito, Dong-Hee Koh, Eun-Young Kim, Hisato Iwata
  • Organizer: SETAC Japan 2018年 年会
  • Int'l Joint Research
• [Presentation] ハンドウイルカの培養細胞を用いた環境汚染物質の免疫・細胞毒性影響評価 (2018)
  • Author(s): 落合真理，西田悠輝，澤 修作，岩田秀一，中郡 翔太郎，岩田久人
  • Organizer: 第二回つくみイルカ研究シンポジウム
• [Presentation] Hepatic proteome profiling in cane toad [rhinella marina] from the Philippines (2018)
  • Author(s): Rosal, J. J., Tsuchiya, M. C., Agusa, T., Hirano, M., Iwata, H.
  • Organizer: SETAC AP 2018
  • Int'l Joint Research
• [Presentation] Characterization of the hepatic transcriptome in chicken AHR2 transgenic mice (2018)
  • Author(s): Park, J-G., Nomura, K., Iwata, H., Kim, E-Y.
  • Organizer: SETAC AP 2018
  • Int'l Joint Research
• [Presentation] Effects of exposure to tris [2-chloroethyl] phosphate [TCEP] on chicken embryos in the shell-less incubation system (2018)
  • Author(s): Kanda, K., Ito, S., Koh, D-H., Kim, E-Y., Iwata, H.
  • Organizer: SETAC AP 2018
  • Int'l Joint Research
• [Presentation] Evaluation of sensitivity of dioxin related chemicals to polar bear [ursus maritimus] AHR (2018)
  • Author(s): Hwang, J-H., Kannan, K., Evans, T. J., Iwata, H., Kim, E-Y.
  • Organizer: SETAC AP 2018
  • Int'l Joint Research
• [Presentation] In vitro and in silico ahr assays for assessing the risk of heavy oilcontaminated marine fish (2018)
  • Author(s): Bak, S. M., Nakata, H., Koh, D-H., Yoo, J., Iwata, H., Kim, E-Y.
  • Organizer: SETAC AP 2018
  • Int'l Joint Research
• [Presentation] Differences in POPs and transcriptomes of wild and hatchery-reared baltic salmons (2018)
  • Author(s): Kanerva, M., Nguyen, M. T., Kunisue, T., Amvuori, K., Iwata, H.
  • Organizer: SETAC AP 2018
  • Int'l Joint Research
• [Presentation] Effect of prenatal bisphenol a exposure on the hepatic transcriptome in chicken embryos: understanding of sexspecific effects (2018)
  • Author(s): Ito, S., Iida, M., Nguyen, H.T., Agusa, T., Hirano, M., Ochiai M., Kim, E-Y., Iwata, H.
  • Organizer: SETAC AP 2018
  • Int'l Joint Research
• [Presentation] Structure-activity relationships of Baikal seal estrogen receptors and environmental phenols (2018)
  • Author(s): Yoshinouchi Y, Hirano M, Nakata H, Nomiyama K, Tanabe S, Kim E-Y, Iwata H
  • Organizer: EUROTOX2018
  • Int'l Joint Research
• [Presentation] In vitro cytotoxicity assessments of persistent organic pollutants using cetacean fibroblasts (2018)
  • Author(s): Ochiai M, Kurihara N, Matsuda A, Nakagun S, Shiozaki A, Nakata A, Matsuishi T, Kunisue T, Iwata H
  • Organizer: EUROTOX2018
  • Int'l Joint Research
• [Presentation] In vitro and in silico approaches for assessing the activation of Baikal seal estrogen receptors by bisphenols and OH-PCBs (2018)
  • Author(s): Yoshinouchi Y, Hirano M, Nakata H, Nomiyama K, Tanabe S, Kim EY, Iwata H
  • Organizer: Dioxin2018
  • Int'l Joint Research
• [Presentation] PCBs as an environmental obesogen in dogs: evidence from hepatic transcriptome, metabolome, and lipidome analyses (2018)
  • Author(s): Tamura S, Agusa T, Hirano M, Eguchi A, Nomiyama K, Li L, Kannan K, Tanabe S, Kim EY, Iwata H
  • Organizer: Dioxin2018
  • Int'l Joint Research
• [Presentation] Develop of in silico computational method for seeking the PPARγ ligand (2018)
  • Author(s): Koh D-H, Song W-S, Hwang J-H, Iwata H, Kim E-Y
  • Organizer: Dioxin2018
  • Int'l Joint Research
• [Presentation] Predicted Adverse Outcome Pathways of Prenatal Exposure to Triclosan in Chicken Embryos (2018)
  • Author(s): Jiahua Guo, Shohei Ito, Hoa Thanh Nguyen, Kimika Yamamoto, Rumi Tanoue, Tatsuya Kunisue, Hisato Iwata
  • Organizer: SOT 57th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] Evaluating estrogenic and anti-estrogenic potency of bisphenol A analogues in vivo and in silico using zebrafish (2018)
  • Author(s): Kubota A, Wakayama Y, Lee JS, Nakamura M, Kawai Y, Yoshinouchi Y, Iwata H, Hirano M, Nakata H
  • Organizer: Dioxin2018
  • Int'l Joint Research
• [Presentation] In Silico Prediction and In Vivo Measurement of Estrogen-Like Effects of Bisphenol Analogues in Zebrafish (2018)
  • Author(s): Kubota A, Wakayama Y, Lee JS, Nakamura M, Kawai Y, Yoshinouchi Y, Iwata H, Hirano M, Nakata H
  • Organizer: SOT 57th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] Transcriptome Analysis Reveals the Mechanism of Transgenerational Effects of Bisphenol A in Rats (2018)
  • Author(s): Hoa Thanh Nguyen, Kimika Yamamoto, Midori Iida, Tatsuya Agusa, Masashi Hirano, Mari Ochiai, Eun-Young Kim, Hisato Iwata
  • Organizer: SOT 57th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] Hepatic Transcriptome Analysis to Assess the Effects of Prenatal Bisphenol A Exposure on Developing Chicken Embryos (2018)
  • Author(s): Shohei Ito, Midori Iida, Hoa Thanh Nguyen, Tetsuro Agusa, Masashi Hirano, Mari Ochiai, Eun-Young Kim, Hisato Iwata
  • Organizer: SOT 57th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] Molecular Mechanisms Underlying Species Differences in Transactivation Potencies of Seal and Dog Estrogen Receptors by OH-PCBs (2018)
  • Author(s): Yuka Yoshinouchi, Hiroki Okuda, Masashi Hirano, Kei Nomiyama, Shinsuke Tanabe, Eun-Young Kim, Hisato Iwata
  • Organizer: SOT 57th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] ミャンマーにおける地下水微量元素汚染の実態 (2018)
  • Author(s): 阿草哲郎, 村上理佳子, 木村直登, 大曲遼, 内山幸子, 有薗幸司, 中田晴彦, Phay Nyunt
  • Organizer: 第27回環境化学討論会
• [Presentation] Environmental Contamination by Metals in Myanmar: Case Study of Arsenic in Groundwater (2018)
  • Author(s): Agusa, T., Murakami, R., Kimura, N., Omagari, R., Uchiyama, Y., Arizono, K., Nakata, H., Phay, N.
  • Organizer: Joint Seminar on Environmental Chemistry for Collaboration Research between Myanmar and Japan
  • Int'l Joint Research
• [Presentation] Microplastic Pollution Originated from Drifted Wastes of Coastal Areas in Kumamoto (2018)
  • Author(s): Shimoda, Y., Oda, A., Matsumoto, Y., Kitahara, K., Nakata, H., Agusa, T.
  • Organizer: Taiwan-Japan International Symposium on Environmental Science, Technology and Management, Taoyuan
  • Int'l Joint Research
• [Presentation] Environmental Effects by Disaster Waste Caused by the Kumamoto Earthquake (2018)
  • Author(s): Kohara, M., Oda, A., Shimoda, Y., Nakata, H., Ueno, D., Agusa, T.
  • Organizer: Taiwan-Japan International Symposium on Environmental Science, Technology and Management, Taoyuan
  • Int'l Joint Research
• [Presentation] Contamination by Arsenic and Other Metals in Groundwater from Myanmar (2018)
  • Author(s): Agusa, T., Murakami, R., Kimura, N., Uchiyama, Y., Omagari, R., Ueda, H., Yoshida, M., Kawasaki, C., Arizono, K., Phay, N., Nakata, H.
  • Organizer: 5th International Arsenic Symposium in Miyazaki ~ Environmental Impact and Health Hazards ~
  • Int'l Joint Research
• [Presentation] Transboundary Pollution by Heavy Metals in East Asia and Its effect on Cetaceans (2018)
  • Author(s): Oda, A., Tsugeki, N.K., Kuwae, M., Tanabe, S., Agusa, T.
  • Organizer: Taiwan-Japan International Symposium on Environmental Science, Technology and Management, Taoyuan
  • Int'l Joint Research
• [Presentation] Genotype Distribution of Arsenic Metabolic Enzymes in Asian Population. (2018)
  • Author(s): Fukuhara, K., Yoshida, A., Ballesteros, F.C., Hayama, S., Takuma, K., Agusa, T.
  • Organizer: Taiwan-Japan International Symposium on Environmental Science, Technology and Management, Taoyuan
  • Int'l Joint Research
• [Presentation] Temporal trend analyses of POPs in three toothed whale species stranded along the Japanese coastal waters: importance of samples and data stored in es-BANK and ChemTHEATRE (2018)
  • Author(s): Tatsuya Kunisue, Kana Egashira, Tomohiko Isobe, Kei Nakayama, Takashi Matsuishi, Yuko Tajima, Tadasu Yamada, Shinsuke Tanabe
  • Organizer: 38th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2018)
  • Int'l Joint Research
• [Presentation] AhR agonists in Japanese wild birds evaluated by chemical analysis and bioassays (2018)
  • Author(s): Machiko Kasuya, Nguyen Minh Tue, Akitoshi Goto, Shinsuke Tanabe, Tatsuya Kunisue
  • Organizer: 38th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2018)
  • Int'l Joint Research
• [Presentation] Coastal monitoring of organohalogen compounds using oysters from Okinawa island, Japan (2018)
  • Author(s): Yukino Mukai, Akitoshi Goto, Yutaka Tashiro, Shinsuke Tanabe, Tatsuya Kunisue
  • Organizer: 38th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2018)
  • Int'l Joint Research
• [Presentation] CALUXによる日本の野生鳥類に残留するダイオキシン類縁化合物の活性評価 (2018)
  • Author(s): 粕谷満知子・Nguyen Minh Tue・後藤 哲智・田辺 信介・国末達也
  • Organizer: 第27回環境化学討論会
• [Presentation] 瀬戸内海のイガイに蓄積するハロゲン化アルカロイドの構造解析 (2018)
  • Author(s): 後藤哲智・Nguyen Minh Tue・田辺 信介・国末達也
  • Organizer: 第27回環境化学討論会
• [Presentation] 沖縄県沿岸のカキを用いた有機ハロゲン化合物の汚染モニタリング (2018)
  • Author(s): 向井幸乃・後藤哲智・田代 豊・田辺信介・国末達也
  • Organizer: 第27回環境化学討論会
• [Presentation] 沖縄島中南部地域における環境中POPsおよびダイオキシン類の分布ハブ、マングース、底質分析による汚染探索 (2018)
  • Author(s): 田代 豊・後藤哲智・国末達也
  • Organizer: 第27回環境化学討論会
• [Presentation] GC×GC-ToFMS による天然有機ハロゲン化合物の網羅的スクリーニング (2018)
  • Author(s): 後藤哲智・Nguyen Minh Tue・田辺 信介・国末達也
  • Organizer: 第66回質量分析総合討論会
• [Presentation] 鯨類の脂皮に蓄積する有機ハロゲン化合物のプロファイル解析 (2018)
  • Author(s): 須之内朋哉・後藤哲智・落合真理・田島木綿子・山田 格・田辺信介・国末達也
  • Organizer: 第29回日本セトロジー研究会
• [Presentation] 瀬戸内海および大村湾のスナメリにおける有機ハロゲン化合物汚染と経年変化 (2018)
  • Author(s): 川邊 陸・後藤哲智・落合真理・山田 格・田島木綿子・天野雅男・田辺信介・国末達也
  • Organizer: 第29回日本セトロジー研究会
• [Presentation] Assessment of estrogenic and anti-estrogenic potency of bisphenol A replacement in zebrafish (2018)
  • Author(s): Jae Seung Lee, Yumi Wakayama, Michiko Nakamura, Yuka Yoshinouchi, Hisato Iwata, Masashi Hirano, Haruhiko Nakata, Yusuke Kawai, Akira Kubota
  • Organizer: 第27回環境化学討論会
• [Presentation] ゼブラフィッシュを用いた生態毒性試験について (2018)
  • Author(s): 久保田彰
  • Organizer: 第12回生態影響試験実習セミナー
  • Invited
• [Presentation] ゼブラフィッシュを用いたビスフェノールA代替物質の 内分泌攪乱作用の評価 (2018)
  • Author(s): 久保田彰、Jae Seung Lee、若山裕己、中村倫子、川合佑典、芳之内結加、岩田久人、平野将司、中田晴彦
  • Organizer: 第45回日本毒性学会学術年会
• [Presentation] 十勝の台風被害による飼料用トウモロコシサイレージのかび毒汚染の実態 (2018)
  • Author(s): 久保田 彰、Jae Seung Lee、川島千帆
  • Organizer: 第45回日本毒性学会学術年会
• [Presentation] タンチョウにおける異物代謝関連遺伝子の同定と定量 (2018)
  • Author(s): 川合佑典、伊藤究、坂本梨果子、吉野智生、飯間裕子、松本文雄、久保田彰
  • Organizer: 第161回日本獣医学会学術集会
• [Presentation] Microplastic Pollution in Freshwater Ecosystem -A Case study of Inland Lakes in Japan. (2018)
  • Author(s): Yoichi Era, Haruhiko Nakata
  • Organizer: North Pacific Marine Science Organization (PICES) Annual Meeting
  • Int'l Joint Research
• [Presentation] Identification of Terrestrial Sources of Microplastics into the Aquatic Environment (2018)
  • Author(s): Kenichi Kitahara, Haruhiko Nakata
  • Organizer: North Pacific Marine Science Organization (PICES) Annual Meeting
  • Int'l Joint Research
• [Presentation] Concentrations and distribution of PAHs and micro-plastic in road dusts collected from Myanmar (2018)
  • Author(s): Ei Ei Mon, Haruhiko Nakata
  • Organizer: 第27回環境化学討論会
• [Presentation] 自然災害を想定した地下水リスク管理に関する基礎研究―熊本県八代市を例に― (2018)
  • Author(s): 山内拓也, 石井絵理, 藤川貴史, 中田晴彦
  • Organizer: 第27回環境化学討論会
• [Presentation] 江津湖におけるマイクロプラスチック汚染の現状把握と発生源推定および影響評価 (2018)
  • Author(s): 恵良要一, 北原健一, 渡邊地洋, 中田晴彦
  • Organizer: 第27回環境化学討論会
• [Presentation] 沿岸性植物によるファイトレメディエーションの可能性評価 (2018)
  • Author(s): 奥谷翔吾, 上田裕己, 中田晴彦
  • Organizer: 第27回環境化学討論会
• [Presentation] 自然災害を想定した地下水リスク管理に関する基礎研究―愛媛県西条市を例に― (2018)
  • Author(s): 石井絵理, 中田晴彦
  • Organizer: 第27回環境化学討論会
• [Presentation] 新規の環境劣化指標に基づく漂着ペットボトルの履歴の経時的検証 (2018)
  • Author(s): 渡邊地洋, 中田晴彦
  • Organizer: 第27回環境化学討論会
• [Presentation] Pilot study on the toxicological assessment of organohalogen compounds in pet cat (Felis catus) serum using metabolomics approach (2018)
  • Author(s): Kei Nomiyama, Akifumi Eguchi, Hazuki Mizukawa, Yasuo Yamamoto, Hiroyuki Nishikawa, Mitsuyoshi Takiguchi, Shouta Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Shinsuke Tanabe
  • Organizer: DIOXIN 2018
  • Int'l Joint Research
• [Presentation] 薬物・環境化学物質の代謝活性化と甲状腺ホルモンへの影響 (2018)
  • Author(s): 野見山 桂
  • Organizer: 環境ホルモン学会第 32 回講演会
  • Invited
• [Presentation] Effects of polychlorinated biphenyls (PCBs) in cats: Exhaustive gene expression analysis approach (2018)
  • Author(s): Hazuki Mizukawa, Kraisiri Khidkhan, Yoshinori Ikenaka, Shouta Nakayama, Kei Nomiyama, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Tsend-ayush Sainnoxoi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: DIOXIN 2018
  • Int'l Joint Research
• [Presentation] Contamination status and global comparison of organohalogen compounds and their related compounds in the pet cats in Thailand. (2018)
  • Author(s): Makoto Shimasaki, Kei Nomiyama, Hazuki Mizukawa, Aksorn Saengtienchai, Araya Ngamchirttakul, Disdanai Pencharee, Yoshinori Ikenaka, Shouta Nakayama, Tatsuya Kunisue, Shinsuke Tanabe
  • Organizer: DIOXIN 2018
  • Int'l Joint Research
• [Presentation] Tissue distribution and CYP expression related-PCBs exposure in cats (2018)
  • Author(s): Kraisiri Khidkhan, Hazuki Mizukawa, Yoshinori Ikenaka, Shouta Nakayama, Wageh Sobhy Darwish, Kei Nomiyama, Mitsuyoshi Takiguchi, Nozomu Yokoyama, Osamu Ichii, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: DIOXIN 2018
  • Int'l Joint Research
• [Presentation] 血清中メタボローム解析によるペットネコ（Felis catus）の有機ハロゲン化合物毒性影響評価 (2018)
  • Author(s): 野見山 桂・江口哲史・西川博之・水川葉月・山本恭央・滝口満喜・中山翔太・池中良徳・石塚真由美・田辺信介
  • Organizer: 第27回環境化学討論会
• [Presentation] LC-MS/MSを用いた脳中甲状腺ホルモンの高感度分析法の開発 (2018)
  • Author(s): 小野純華・高口倖暉・田上瑠美・国末達也・田辺信介・野見山 桂
  • Organizer: 第27回環境化学討論会
• [Presentation] 液体クロマトグラフタンデム質量分析計(LC-MS/MS)を用いた脳中神経伝達物質とその代謝物の分析法開発 (2018)
  • Author(s): 野島由衣・野見山 桂・田上瑠美・国末達也・田辺信介
  • Organizer: 第27回環境化学討論会
• [Presentation] 有機ハロゲン化合物曝露によるネコの生化学マーカーの変化および甲状腺機能に及ぼす影響評価 (2018)
  • Author(s): 水川葉月・Khidkhan. K.・高口倖暉・横山 望・市居 修・滝口満喜・笹岡一慶・池中良徳・中山翔太・Tsendayush, S.・野見山 桂・田辺信介・石塚真由美
  • Organizer: 第27回環境化学討論会
• [Presentation] ネコのin vivo BDE209 長期曝露試験による体内動態の解明および甲状腺ホルモンへの影響評価 (2018)
  • Author(s): 田中啓介・野見山 桂・水川葉月・高口倖暉・田上瑠美・横山 望・市居 修・滝口満喜・中山翔太・池中良徳・石塚真由美・国末達也・田辺信介
  • Organizer: 第27回環境化学討論会
• [Book] Arsenic Contamination in Asia (2018)
  • Author(s): Kobayashi, Y., Agusa, T.
  • Total Pages: 211
  • Publisher: Springer Nature
  • ISBN: 978-981-13-2564-9
• [Remarks] 愛媛大学沿岸環境科学研究センター岩田研究室（日本語版）
  • URL: http://ecotoxiwata.jp/
• [Remarks] 愛媛大学沿岸環境科学研究センター岩田研究室（英語版）
  • URL: http://ecotoxiwata.jp/en/index.html
• [Remarks] 日本学術振興会「私と科研費」「私の研究者人生と科研費」
  • URL: https://www.jsps.go.jp/j-grantsinaid/29_essay/no93.html
• [Remarks] 愛媛大学沿岸環境科学研究センター岩田研究室のFacebook
  • URL: http://fb.com/101980470429606
• [Remarks] 知の拠点セミナー「野生動物の健康を評価する環境毒性学」
  • URL: http://www.yomiuri.co.jp/science/feature/CO005189/20180206-OYT8T50113.html