アミロイドβの毒性配座理論を基盤としたアルツハイマー病の新しい予防戦略

Products Report

• Project/Area Number: 26221202
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Bioorganic chemistry
• Research Institution: Kyoto University
• Principal Investigator: Irie Kazuhiro 京都大学, 農学研究科, 教授 (00168535)
• Co-Investigator(Kenkyū-buntansha): 久米 利明 富山大学, 大学院医学薬学研究部(薬学), 教授 (10303843) ; 清水 孝彦 千葉大学, 大学院医学研究院, 講師 (40301791) ; 徳田 隆彦 京都府立医科大学, 医学(系)研究科(研究院), 教授 (80242692) ; 村上 一馬 京都大学, 農学研究科, 准教授 (80571281) ; 喜田 昭子 京都大学, 複合原子力科学研究所, 助教 (70273430)
• Project Period (FY): 2014-05-30 – 2019-03-31

Research Products

• [Journal Article] Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation (2023)
  • Author(s): Taniwa Kota, Murakami Kazuma, Sakaguchi Yoshiki, Izuo Naotaka, Hanaki Mizuho, Sampa Nobuaki, Kume Toshiaki, Shimizu Takahiko, Irie Kazuhiro
  • Journal Title: Journal of Agricultural and Food Chemistry Volume: 71 Pages: 14289-14299
  • DOI: 10.1021/acs.jafc.3c02598
  • Peer Reviewed
• [Journal Article] APP knock-in mice produce E22P-Aβ exhibiting an Alzheimer's disease-like phenotype with dysregulation of hypoxia-inducible factor expression (2022)
  • Author(s): Maki Takahito, Sawahata Masahito, Akutsu Ichiro, Amaike Shohei, Hiramatsu Genki, Uta Daisuke, Izuo Naotaka, Shimizu Takahiko, Irie Kazuhiro, Kume Toshiaki
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Pages: 13259
  • DOI: 10.3390/ijms232113259
  • Peer Reviewed / Open Access
• [Journal Article] Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo (2022)
  • Author(s): Murakami Kazuma, Sakaguchi Yoshiki, Taniwa Kota, Izuo Naotaka, Hanaki Mizuho, Kawase Taiji, Hirose Kenji, Shimizu Takahiko, Irie Kazuhiro
  • Journal Title: RSC Chemical Biology Volume: 3 Pages: 1380-1396
  • DOI: 10.1039/d2cb00194b
  • Peer Reviewed / Open Access
• [Journal Article] Searching for natural products that delay nucleation phase and promote elongation phase of amyloid beta42 toward Alzheimer's disease therapeutics (2021)
  • Author(s): Murakami Kazuma, Horii Shiori, Hanaki Mizuho, Irie Kazuhiro
  • Journal Title: ACS Chemical Neuroscience Volume: 12 Pages: 3467-3476
  • DOI: 10.1021/acschemneuro.1c00489
  • Peer Reviewed
• [Journal Article] アミロイドタンパク質を認識する核酸アプタマー (2021)
  • Author(s): 村上一馬、入江一浩
  • Journal Title: 化学と生物 Volume: 59 Pages: 216-218
• [Journal Article] 毒性配座アミロイドβに着目した新規アルツハイマー病モデルマウスの開発 (2021)
  • Author(s): 泉尾直孝、清水孝彦、村上一馬、入江一浩
  • Journal Title: 薬学雑誌 Volume: 141 Pages: 843-849
  • DOI: 10.1248/yakushi.20-00251-5
• [Journal Article] Detection of amyloid beta oligomers with RNA aptamers in APP^<NL-G-F/NL-G-F> mice : a model of arctic Alzheimer's disease (2020)
  • Author(s): Obata Yayoi, Murakami Kazuma, Kawase Taiji, Hirose Kenji, Izuo Naotaka, Shimizu Takahiko, Irie Kazuhiro
  • Journal Title: ACS Omega Volume: 5 Pages: 21531-21537
  • DOI: 10.1021/acsomega.0c02134
  • Peer Reviewed
• [Journal Article] New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β (2020)
  • Author(s): Irie Kazuhiro
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 84 Pages: 1-16
  • DOI: 10.1080/09168451.2019.1667222
  • Peer Reviewed
• [Journal Article] An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease (2020)
  • Author(s): Murakami Kazuma, Obata Yayoi, Sekikawa Asa, Ueda Haruka, Awano Tatsuya, Takabe Keiji, Takahiko Shimizu, Irie Kazuhiro
  • Journal Title: The Journal of Biological Chemistry
  • DOI: 10.1074/jbc.RA119.010955
  • Peer Reviewed
• [Journal Article] An RNA aptamer with potent affinity for a toxic dimer of amyloid β 42 has potential utility for histochemical studies of Alzheimer's disease (2020)
  • Author(s): Murakami Kazuma, Obata Yayoi, Sekikawa Asa, Ueda Haruka, Awano Tatsuya, Takabe Keiji, Takahiko Shimizu, Irie Kazuhiro
  • Journal Title: The Journal of Biological Chemistry Volume: 295 Pages: 4870-4880
  • DOI: 10.1074/jbc.RA119.010955
  • Peer Reviewed
• [Journal Article] Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology (2020)
  • Author(s): Murakami Kazuma, Kato Haruka, Hanaki Mizuho, Monobe Yoko, Akagi Ken-ichi, Kawase Taiji, Hirose Kenji, Irie Kazuhiro
  • Journal Title: RSC Advances Volume: 10 Pages: 19506-19512
  • DOI: 10.1039/d0ra03429k
  • Peer Reviewed / Open Access
• [Journal Article] An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease (2019)
  • Author(s): Izuo Naotaka, Murakami Kazuma, Fujihara Yoshitaka, Maeda Masahiro, Saito Takashi, Saido C. Takaomi, Irie Kazuhiro, Shimizu Takahiko
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 515 Pages: 462-467
  • DOI: 10.1016/j.bbrc.2019.05.131
  • Peer Reviewed
• [Journal Article] アミロイドβの毒性2量体および3量体モデルの合成と構造機能解析 (2019)
  • Author(s): 入江 一浩
  • Journal Title: 有機合成化学協会誌 Volume: 77 Pages: 1201-1208
  • DOI: 10.5059/yukigoseikyokaishi.77.1201
  • Peer Reviewed
• [Journal Article] Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties (2019)
  • Author(s): Murakami Kazuma, Irie Kazuhiro
  • Journal Title: Molecules Volume: 24 Pages: 2125
  • DOI: 10.3390/molecules24112125
  • Peer Reviewed / Open Access