Neural mechanisms of visual communications revealed with electrocorticography.

2016 Fiscal Year Annual Research Report

• Project/Area Number: 26242088
• Research Institution: Niigata University
• Principal Investigator: 長谷川 功 新潟大学, 医歯学系, 教授 (60282620)
• Co-Investigator(Kenkyū-buntansha): 奥田 修二郎 新潟大学, 医歯学系, 准教授 (00512310) ; 谷川 久 新潟大学, 研究推進機構, 准教授 (40373328) ; 中原 潔 高知工科大学, 総合研究所, 教授 (50372363) ; 神谷 之康 株式会社国際電気通信基礎技術研究所, 脳情報通信総合研究所, 研究室長 (50418513) ; 河野 剛士 豊橋技術科学大学, 工学(系)研究科(研究院), 准教授 (70452216) ; 鎌田 恭輔 旭川医科大学, 医学部, 教授 (80372374)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 皮質脳波 / 視覚 / 前頭葉 / 信号伝搬

Outline of Annual Research Achievements

様々な空間スケールで計測した皮質脳波（Electrocorticography: ECoG）の時空間パターンから視覚的コミュニケーションを担う階層的/再帰的な大脳神経回路における情報表現と伝播を明らかにすることを目指し、A下側頭葉IT野における局所伝達エントロピー（Local Transfer Entropy: LTE）の定量化、B視覚野周辺抑制における微視的皮質回路の再帰的信号処理、C 記号の分節化を担う前頭前野の機能分化と情報処理の流れ、D 社会認知における脳内の情報流、E視覚イメージ想起における側頭葉と前頭葉の階層的信号の流れ、という5つの下位目標に沿って実験・解析を進めた。Aでは、マカクザルIT野における情報流は解剖学的な階層性に一致してITの前後軸に沿った流れとして捉えられ、視覚情報処理にともなって順行性の流れと逆行性の流れが交互に現れること、行性と逆行性のネットワークでは情報トポロジーや情報の分離と統合の仕方に違いがあることを明らかにした。Bでは、ラット1次視覚野から0.1mm間隔で超高密度記録したECoGの時間-空間2次元フーリエ変換を施し、1次視覚野の大域的・局所的興奮とカラム様の規模（約0.2mm）の周辺抑制に相当する電場電位を捉え、その空間的・時間的周期構造を特定した。Cでは、物を見てそれを表す記号を想起したうえでその記号を要素に分節化する課題を遂行中のマカクザルの前頭皮質において、単に物から記号への変換や、視覚的に提示した記号の分節化の線形和以上の低周波帯域の活動を発見した。Dでは、社会認知課題を遂行中のサルの前頭葉内側部からのECoG計測と同時に視床枕から微小電極法による計測を行って情報流を解析している。Eでは視覚イメージの連想学習によるサル内側側頭葉におけるECoG広域空間パターンが変化することを明らかにした。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] The ProteomeXchange Consortium in 2017: supporting the cultural change in proteomics public data deposition. (2017)
  • Author(s): Deutsch, E. W., Csordas, A., Sun, Z., Jarnuczak, A., Perez-Riverol, Y., Ternent, T., Campbell, D. S., Bernal-Llinares, M., Okuda, S., Kawano, S., Moritz, R. L., Carver, J. J., Wang, M., Ishihama, Y., Bandeira, N., Hermjakob, H., Vizcaíno, J. A.
  • Journal Title: Nucleic Acids Res. Volume: 45 Pages: D1100-D1106
  • DOI: 10.1093/nar/gkw936
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] jPOSTrepo: an international standard data repository for proteomes. (2017)
  • Author(s): Okuda, S., Watanabe, Y., Moriya, Y., Kawano, S., Yamamoto, T., Matsumoto, M., Takami, T., Kobayashi, D., Araki, N., Yoshizawa, A. C., Tabata, T., Sugiyama, N., Goto, S., Ishihama, Y.
  • Journal Title: Nucleic Acids Res. Volume: 45 Pages: D1107-D1111
  • DOI: 10.1093/nar/gkw1080
  • Peer Reviewed / Open Access
• [Journal Article] Poly(ADP-ribose) Polymerase Inhibitors Activate the p53 Signaling Pathway in Neural Stem/Progenitor Cells. (2017)
  • Author(s): Okuda, A., Kurokawa, S., Takehashi, M., Maeda, A., Fukuda, K., Kubo, Y., Nogusa, H., Takatani-Nakase, T., Okuda, S., Ueda, K., Tanaka, S.
  • Journal Title: BMC Neurosci. Volume: 18 Pages: 14
  • DOI: 10.1186/s12868-016-0333-0
  • Open Access
• [Journal Article] Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex. (2016)
  • Author(s): Nakahara K, Adachi K, Kawasaki K, Matsuo T, Sawahata H, Majima K, Takeda M, Sugiyama S, Nakata R, Iijima A, Tanigawa H, Suzuki T, Kamitani Y, Hasegawa I.
  • Journal Title: Nature Communications Volume: 7 Pages: 11827
  • DOI: 10.1038/ncomms11827
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] BrainLiner: A neuroinformatics platform for sharing time-aligned brain-behavior data. (2016)
  • Author(s): Takemiya M, Majima K, Tsukamoto M, Kamitani Y,
  • Journal Title: Frontiers in Neuroinformatics Volume: - Pages: -
  • DOI: 10.3389/fninf.2016.00003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Single 5 µm Diameter Needle-electrode Block Modules for Unit Recordings in vivo. (2016)
  • Author(s): H. Sawahata, S. Yamagiwa, A. Moriya, D. S. Teo, H. Oi, Y. Ando, R. Numano, M. Ishida, K. Koida, T. Kawano,
  • Journal Title: Scientific Reports Volume: 6 Pages: 35806
  • DOI: 10.1038/srep35806
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nanoscale-tipped High-aspect-ratio Vertical Microneedle Electrodes for Intracellular Recordings. (2016)
  • Author(s): Y. Kubota, H. Oi, H. Sawahata, A. Goryu, Y. Ando, R. Numano, M. Ishida, T. Kawano,
  • Journal Title: Small Volume: 12 Pages: 2846-2853
  • DOI: 10.1002/smll.201600172
  • Peer Reviewed
• [Journal Article] Reflectance Imaging by Fiber Bundle Endoscope: Vertical Reconstruction by Multipositional Illumination (2016)
  • Author(s): Y. Ando, K. Koida, H. Sawahata, T. Sakurai, M. Natsume, T. Kawano, R. Numano,
  • Journal Title: AIP Conference Proceedings Volume: 1709 Pages: 020009
  • DOI: http://dx.doi.org/10.1063/1.4941208
  • Peer Reviewed
• [Journal Article] GlyTouCan 1.0 -The international glycan structure repository. (2016)
  • Author(s): Aoki-Kinoshita, K., Aoki, N. P., Shinmachi, D., Fujita, A., Tsuchiya, S., Matsubara, M., Okuda, S., Fujita, N., Yamada, I., Narimatsu, H.
  • Journal Title: Nucleuc Acids Res. Volume: 44 Pages: D1237-D1242
  • DOI: 10.1093/nar/gkv1041
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Enzyme Genes Using Chemical Structure Alignments of Substrate-Product Pairs. (2016)
  • Author(s): Moriya, Y., Yamada, T., Okuda, S., Nakagawa, Z., Kotera, M., Tokimatsu, T., Kanehisa, M., Goto, S.
  • Journal Title: J. Chem. Inf. Model. Volume: 56 Pages: 510-516
  • DOI: 10.1021/acs.jcim.5b00216
  • Peer Reviewed
• [Journal Article] Rare UNC13B variations and risk of schizophrenia: Whole-exome sequencing in a multiplex family and follow-up resequencing and case -control study. (2016)
  • Author(s): Egawa, J., Hoya, S., Watanabe, Y., Nunokawa, A., Shibuya, M., Ikeda, M., Inoue, E., Okuda, S., Kondo, K., Saito, T., Kaneko, N., Muratake, T., Igeta, H., Iwata, N., Someya, T.
  • Journal Title: Am. J. Med. Genet.Part B Neuropsychiatr Genet. Volume: 171 Pages: 797-805
  • DOI: 10.1002/ajmg.b.32444
  • Peer Reviewed
• [Journal Article] Species-function relationships shape ecological properties of the human gut microbiome. (2016)
  • Author(s): Vieira-Silva, S., Falony, G., Lima-Mendez, G., Darzi, Y., Yunta, R., G., Okuda, S., Vandeputte, D., Hildebrand, F., Chaffron, S., Raes, J.
  • Journal Title: Nat. Microbiol. Volume: 1 Pages: 16088
  • DOI: 10.1038/nmicrobiol.2016.88
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. (2016)
  • Author(s): Saito, T., Waguri, S., Ohishi, M., Endo, K., Uemura, T., Taguchi, K., Hirose, Y., Nagahashi, N., Nishito, Y., Okuda, S., Fujimura, T., Lee, M-S., Ueno, T., Wakai, T., Motohashi, H., Yamamoto, M., Tanaka, K., Soga, T., Komatsu, M.
  • Journal Title: Nat. Commun. Volume: 7 Pages: 12030
  • DOI: 10.1038/ncomms12030
  • Peer Reviewed / Open Access
• [Journal Article] An adenylyl cyclase with a phosphodiesterase domain in basal plants with a motile sperm system. (2016)
  • Author(s): Kasahara, M., Suetsugu, N., Urano, Y., Yamamoto, C., Ohmori, M., Takada, Y., Okuda, S., Nishiyama, T., Sakayama, H., Kohchi, T., Takahashi, F.
  • Journal Title: Sci. Rep. Volume: 6 Pages: 39232
  • DOI: 10.1038/srep39232
  • Peer Reviewed / Open Access
• [Journal Article] Mutations in SDR9C7 gene encoding an enzyme for vitamin A metabolism underlie autosomal recessive congenital ichthyosis. (2016)
  • Author(s): Shigehara,Y., Okuda, S., Hayashi,R., Nakai, H., Abe, R., Kurban, M., Shimomura, Y.
  • Journal Title: Hum. Mol. Genet. Volume: 25 Pages: 4484-4493
  • DOI: https://doi.org/10.1093/hmg/ddw277
  • Peer Reviewed
• [Journal Article] Genomic landscape of colorectal cancer in Japan: Clinical implications of comprehensive genomic sequencing for precision medicine. (2016)
  • Author(s): Nagahashi M, Wakai T, Shimada Y, Ichikawa H, Kameyama H, Kobayashi T, Sakata J, Sato N, Kitagawa Y, Uetake H, Yoshida K, Oki E, Kudo S, Izutsu H, Komada K, Nakada M, Tse J, Russelｌ M, Heyer J, Powers W, Sun R, Ring J. E, Takabe K, Protopopov A, Ling Y, Okuda S, Lyle S.
  • Journal Title: Genome Medicine Volume: 8 Pages: 136
  • DOI: 10.1186/s13073-016-0387-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Magnetoencephalographic-based brain-machine interface robotic hand for controlling sensorimotor cortical plasticity and phantom limb pain (2017)
  • Author(s): Yanagisawa T, Fukuma R, Ben Seymour, Hosomi K, Kishima H, Shimizu T, Yokoi H, Yoshimine T, Kamitani Y,Satoh Y.
  • Organizer: 6th European Conference on Clinical Neuroimaging
  • Place of Presentation: Roma (Italy)
  • Year and Date: 2017-03-27 – 2017-03-28
  • Int'l Joint Research
• [Presentation] Ultra High-aspect-ratio Neuroprobe: 5-μm-diameter and 400-μm-length Needle Detects Action Potentials in vivo (2017)
  • Author(s): S. Yamagiwa, H. Sawahata, H. Oi, R. Numano, M. Ishida, T. Kawano.
  • Organizer: IEEE Micro Electro Mechanical Systems (IEEE-MEMS) Conference 2017
  • Place of Presentation: Las Vegas (U.S.A)
  • Year and Date: 2017-01-22 – 2017-01-26
  • Int'l Joint Research
• [Presentation] Hook and Loop Microfastener: Flexible Microelectrodes Tied to a Nerve (2017)
  • Author(s): Y. Seki, S. Yamagiwa, Y. Morikawa, H. Sawahata, R. Numano, M. Ishida, T. Kawano.
  • Organizer: IEEE Micro Electro Mechanical Systems (IEEE-MEMS) Conference 2017
  • Place of Presentation: Las Vegas (U.S.A)
  • Year and Date: 2017-01-22 – 2017-01-26
  • Int'l Joint Research
• [Presentation] Modulation of value information coded in the lateral prefrontal cortex by decode neurofeedback with electrocorticographic (ECoG) signals. (2016)
  • Author(s): Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Sakagami M.
  • Organizer: Neuroscience2016
  • Place of Presentation: San Diego (U.S.A)
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Decoding recalled color imagery using ECoG signals in macaque inferior temporal and prefrontal cortices. (2016)
  • Author(s): Tanigawa H, Majima K, Takei R, Kawasaki K, Sawahata H, Nakahara K, Suzuki T, Kamitani Y, Hasegawa I.
  • Organizer: Neuroscience2016
  • Place of Presentation: San Diego (U.S.A)
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Relationships between the internal representations of convolutional neural network and the space, time and frequency domains of ECoG signals on macaque inferior temporal cortex. (2016)
  • Author(s): Date H, Kawasaki K, Ozay M, Hongo T, Hasegawa I, Okatani T.
  • Organizer: Neuroscience2016
  • Place of Presentation: San Diego (U.S.A)
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Relationships between ongoing activity fluctuation in the medial temporal lobe and subsequent memory performance. (2016)
  • Author(s): R. Keerativittayayut, R. Aoki, M. Taghizadeh Sarabi, K. Nakahara.
  • Organizer: Neuroscience2016
  • Place of Presentation: San Diego (U.S.A)
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Feasibility of multiband EPI for detection of brain activation in the reward system. (2016)
  • Author(s): M. Taghizadeh Sarabi, R. Aoki, R. Keerativittayayut, K. Nakahara.
  • Organizer: Neuroscience2016
  • Place of Presentation: San Diego (U.S.A)
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] 腕神経叢引き抜き損傷後疼痛に対するDREZotomyからDecNef (2016)
  • Author(s): 柳澤琢史、細見晃一、福間良平、清水豪士、貴島晴彦、平田雅之、横井浩史、吉峰俊樹、神谷之康、齊藤洋一
  • Organizer: 日本脳神経学会第75回学術総会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-09-29 – 2016-10-01
• [Presentation] Micro/nanoscale Needle Technology for Brain (2016)
  • Author(s): T. Kawano
  • Organizer: 16th International Conference on Nanotechnology (IEEE NANO)
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-08-22 – 2016-08-25
  • Int'l Joint Research / Invited
• [Presentation] 3D microtube and 2D flexible film waveguide devices (2016)
  • Author(s): T. Kawano
  • Organizer: 2016 International Conference on Optical MEMS and Nanophotonics (OMN)
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2016-07-31 – 2016-08-04
  • Int'l Joint Research / Invited
• [Presentation] Directional influences through theta band activity between macaque inferior temporal and prefrontal cortices during memory retrieval. (2016)
  • Author(s): Sasaki H, Tanigawa H, Kawasaki K, Iijima A, Suzuki T, Hasegawa H.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20 – 2016-07-22
  • Int'l Joint Research
• [Presentation] Correspondence between the representations of convolutional neural networks and the activities in inferior temporal cortex measured by electrocorticography. (2016)
  • Author(s): Date H, Kawasaki K, Ozay M, Hongo T, Hasegawa I, Okatani T.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20 – 2016-07-22
  • Int'l Joint Research
• [Presentation] Direction-specific spectral shift of local field potentials in the rat visual cortics found by a combination of electrocorticogram and optogenetics. (2016)
  • Author(s): Toda H, Kawasaki K, Horie M, Nakahara K, Bepari K Asim, Sawahata H, Suzuki T, Takebayasi H, Hasegawa I.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20 – 2016-07-22
  • Int'l Joint Research
• [Presentation] Mismatch negativity in macaque auditory cortex is composed of several components of auditory stimuli. (2016)
  • Author(s): Suda Y, Tada M, Matsuo T, Kawasaki K, Suzuki T, Hasegawa I, Matsumoto K, Kasai K, Uka T.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20 – 2016-07-22
  • Int'l Joint Research
• [Presentation] Decoding the value related information from the ECoG signal recorded from the multiple areas of the prefrontal cortex. (2016)
  • Author(s): Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Sakagami M.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20 – 2016-07-22
  • Int'l Joint Research
• [Presentation] Learninng to signify objects by construction of visual double-articulated signs from elements in macaque monkeys(Macaca Fuscata). (2016)
  • Author(s): Ohashi K, Iijima A, Miyajima T, Iwata Y, Hasegawa I.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20 – 2016-07-22
  • Int'l Joint Research