Search for innovative diagnostic and therapeutic seeds based on next generation OMICS analysis using new disease models

2017 Fiscal Year Final Research Report

• Project/Area Number: 26253078
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kyoto University
• Principal Investigator: Ogawa Osamu 京都大学, 医学研究科, 教授 (90260611)
• Co-Investigator(Kenkyū-buntansha): 井上 貴博 京都大学, 医学(系)研究科(研究院), 助教 (80511881) ; 根来 宏光 京都大学, 医学研究科, 助教 (80708595) ; 神波 大己 京都大学, 医学研究科, 准教授 (20402836) ; 松井 喜之 京都大学, 医学(系)研究科(研究院), 助教 (00582107)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: omics / 質量分析 / 前立腺癌 / 腎癌 / xenograft

Outline of Final Research Achievements

We have established patient-derived tumor tissue (PDTT) xenograft models of urological cancer. Those models show diversity in response to treatment like clinical patients. We have analyzed tumor tissues and body fluid of the PDTT xenograft models by next generation high sensitive mass spectrometry, and identified new molecules related to cancer malignancy and treatment resistance. We are planning to evaluate whether those molecules could be biomarkers or therapeutic targets in clinical setting.

Free Research Field

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