Development of epigenome biomakers reflecting the eating habit

2016 Fiscal Year Final Research Report

• Project/Area Number: 26282027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Shizuoka
• Principal Investigator: GODA Toshinao 静岡県立大学, 食品栄養科学部, 教授 (70195923)
• Co-Investigator(Kenkyū-buntansha): 市川 陽子 静岡県立大学, 食品栄養科学部, 准教授 (50269495) ; 望月 和樹 山梨大学, 総合研究部, 准教授 (80423838) ; 本間 一江 静岡県立大学, 食品栄養科学部, 助教 (80724765)
• Co-Investigator(Renkei-kenkyūsha): KOBAYASHI Kimiko 静岡県立大学, 食品栄養科学部, 教授 (90215319)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: エピゲノム / バイオマーカー / 食後高血糖 / 慢性炎症 / 末梢血

Outline of Final Research Achievements

We have demonstrated using animal models of type two diabetes and obesity that the history of postprandial hyperglycemia is reflected by a change in the responding capability regarding the expression of the genes related to inflammation and insulin resistance in the peripheral leukocytes and the liver. The mononuclear cells exposed to a high glucose concentration for 24h showed persistently elevated levels of the mRNA and histone H3 acetylation (an epigenetic modification) of TNFa gene, which plays a pivotal role in inflammation and insulin resistance. Candidates of epigenome biomarkers for the history of postprandial glucose spikes include a hepatocyte-derived micro RNA and plasma soluble cell adhesion molecules.

Free Research Field

保健栄養学