Low overpressure shock wave for treatment in the deep brain

2016 Fiscal Year Final Research Report

• Project/Area Number: 26282116
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tohoku University
• Principal Investigator: TOMINAGA Teiji 東北大学, 医学(系)研究科(研究院), 教授 (00217548)
• Co-Investigator(Kenkyū-buntansha): 齋藤 竜太 東北大学, 医学(系)研究科(研究院), 助教 (10400243) ; 中川 敦寛 東北大学, 大学病院, 助教 (10447162) ; 大谷 清伸 東北大学, 流体科学研究所, 助教 (80536748) ; 合田 圭介 東京大学, 理学(系)研究科(研究院), 教授 (70518696)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 衝撃波 / 低侵襲治療 / 医工学 / 医療機器

Outline of Final Research Achievements

The purpose of present study is to clarify the effect of low overpressure shock wave (SW) in the central nervous system and to obtain basic understanding for development of drug delivery system using SW in the deep brain lesion. We first applied low overpressure SW in the animal brain and evaluated histological findings. We also evaluated the wave propagation in the brain phantom using high speed photograph and pressure measurement. We then made prototype for low overpressure SW applicator and applied dye liquid in the porcine brain after craniotomy and showed that application of low overpressure SW enhances the distribution of dye compared to mere injection of small amount liquid.

Free Research Field

脳神経外科学