Development of coherent Raman imaging method for diagnosing Alzheimers Disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26282117
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: University of Tsukuba
• Principal Investigator: KANO Hideaki 筑波大学, 数理物質系, 准教授 (70334240)
• Co-Investigator(Kenkyū-buntansha): 加治 優一 筑波大学, 医学医療系, 准教授 (50361332)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ラマン / CARS / 水晶体 / アルツハイマー

Outline of Final Research Achievements

In the present study, we focused on amyloid beta (Aβ) proteins in　an eye lens for diagnosing Alzheimer's disease (AD). Based on the coherent Raman scattering technique, we tried to develop a novel label-free diagnostic system to detect Aβ in an eye lens. We succeeded in obtaining label-free ex vivo images of human eye lens, but we could not find any spectroscopic signature of Aβ within the research period. One of the noteworthy results is that we unexpectedly visualized organelles called rootlet in photoreceptor cells with label-free manner.

Free Research Field

分子分光学