2016 Fiscal Year Final Research Report
Development of breast tumor imaging using near-fluorescent novel-metal clusters
| Project/Area Number |
26282129
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Jin Takashi 国立研究開発法人理化学研究所, 生命システム研究センター, チームリーダー (80206367)
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| Co-Investigator(Kenkyū-buntansha) |
塚崎 克和 国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (70452381)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 生体イメージング / 近赤外 / 蛍光 / 乳がん / 貴金属ナノクラスター |
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| Outline of Final Research Achievements |
In this study, we prepared near-infrared (NIR) emitting gold nanocluster (AuNCs) protected by bovine serum albumin (BSA) for in vivo fluorescence imaging. The emission maximum of the NIR-emitting AuNCs was 700 nm, and its fluorescence quantum yield was 1.7 % in phosphate buffered saline. For breast tumor imaging, anti-HER2 antibody (Herceptin) was conjugated to the AuNCs by using carbodiimide coupling. NIR fluorescence imaging of the breast tumors was achieved for human breast cancer cell implanted nude mice using HER2-AuNCs
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| Free Research Field |
ナノーバイオマテリアル
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