2016 Fiscal Year Final Research Report
Nanomix for a future treatment approach of metabolic syndrome
Project/Area Number |
26282132
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | National Institute of Advanced Industrial Science and Technology (2016) Hokkaido University (2014-2015) |
Principal Investigator |
Kajimoto Kazuaki 国立研究開発法人産業技術総合研究所, 健康工学研究部門, 主任研究員 (10416216)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | ドラッグデリバリーシステム / リポソーム / 肥満 / 脂肪組織 / 血管 |
Outline of Final Research Achievements |
The aims of this study are to develop an original targeting ligand to adipose vasculature and a new functional medicine for obesity treatment. Regarding the original ligand development, we succeeded to identify a novel single-strand DNA aptamer which has in vivo targeting ability to the adipose vasculature in vivo. In addition, we also proved that the DNA aptamer-modified nano DDS (drug delivery system) has significant anti-obesity effects in the mouse model of diet-induced obesity. Next, we focused curcumin as a new functional medicine and succeeded to establish an efficient methodology for preparation of curcumin-loaded nano DDS. We also proved that the curcumin-loaded nano DDS has pro-apoptotic ability in vitro. In the near future, we proceed to in vivo functional assessments of a novel system composed of the original ligands and curcumin for treatment of obesity.
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Free Research Field |
薬物送達学
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