Nanomix for a future treatment approach of metabolic syndrome

2016 Fiscal Year Final Research Report

• Project/Area Number: 26282132
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Institute of Advanced Industrial Science and Technology (2016); Hokkaido University (2014-2015)
• Principal Investigator: Kajimoto Kazuaki 国立研究開発法人産業技術総合研究所, 健康工学研究部門, 主任研究員 (10416216)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ドラッグデリバリーシステム / リポソーム / 肥満 / 脂肪組織 / 血管

Outline of Final Research Achievements

The aims of this study are to develop an original targeting ligand to adipose vasculature and a new functional medicine for obesity treatment. Regarding the original ligand development, we succeeded to identify a novel single-strand DNA aptamer which has in vivo targeting ability to the adipose vasculature in vivo. In addition, we also proved that the DNA aptamer-modified nano DDS (drug delivery system) has significant anti-obesity effects in the mouse model of diet-induced obesity. Next, we focused curcumin as a new functional medicine and succeeded to establish an efficient methodology for preparation of curcumin-loaded nano DDS. We also proved that the curcumin-loaded nano DDS has pro-apoptotic ability in vitro. In the near future, we proceed to in vivo functional assessments of a novel system composed of the original ligands and curcumin for treatment of obesity.

Free Research Field

薬物送達学