Anatomo-functional investigation of ventral language pathway: A combined electrocorticographic recording and stimulation study

2017 Fiscal Year Annual Research Report

• Project/Area Number: 26282218
• Research Institution: Kyoto University
• Principal Investigator: 松本 理器 京都大学, 医学研究科, 准教授 (00378754)
• Co-Investigator(Kenkyū-buntansha): 池田 昭夫 京都大学, 医学研究科, 特定教授 (90212761) ; 下竹 昭寛 京都大学, 医学研究科, 特定助教 (80726000) ; 菊池 隆幸 京都大学, 医学研究科, 助教 (40625084) ; 齊藤 智 京都大学, 教育学研究科, 教授 (70253242) ; 國枝 武治 愛媛大学, 医学系研究科, 教授 (60609931) ; 澤本 伸克 京都大学, 医学研究科, 教授 (90397547)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 腹側言語経路 / 意味認知機能 / 言語 / 皮質電気刺激 / 神経心理 / 機能代償 / デコーディング

Outline of Annual Research Achievements

腹側言語経路の機能・解剖、病態下の代償機転の包括的解明、に基づいて研究を推進した。術前評価に硬膜下電極を慢性留置した難治てんかん外科患者、腫瘍摘出に覚醒下手術を施行した患者で研究に同意を得た者を対象とした。腹側言語経路内の機能の解明に関しては、意味表象のRSA解析(Chen et al. 2016)、support vector machineを応用した運動判別のdecoding（論文発表）の経験から、システムレベル・局所レベルのdecoding解析や領域間の実効的結合性解析を推進し、国内（函館未来大学）・国際（ジョンスホプキンス大学、マンチェスター大学）共同研究として、ネットワークレベルの意味カテゴリ再現や機能連関の解明に着手した（国際学会発表予定）。
漢字/かな読み課題に同期した皮質刺激介入研究では５症例をまとめ、定量的な精神物理学的評価から腹側経路前後方向の意味から形態認知への機能勾配を明らかにした。また、日本語の読み書きにおいて、腹側言語経路の縁上回と背側言語経路の前部紡錘回への刺激介入から、意味理解と音韻の二重解離が出現することを明らかにした(国内・国際学会発表、論文準備中)。脳機能結合地図作成に関しては、覚醒下手術中の皮質・白質の電気刺激研究から、左下前頭回内の結合の機能勾配を明らかにした。眼窩部は腹側言語経路を担い前側頭葉に結合し、弁蓋部は背側言語経路を担い後部側頭葉に結合し、中間の三角部は中間的な結合様式であった (国際学会発表、論文準備中、論文発表)。
腹側言語経路に位置するてんかん焦点・脳腫瘍の切除術前後の経時的な神経心理学的評価(意味認知課題、漢字・かな関連課題)をすすめ症例を蓄積した。言語優位半球側頭葉の前下方領域の切除で、意味記憶障害が出現し、意味性認知症患者と同様の表象失読・失書が出現すること、そして1年以内に機能代償機転から回復に向かうことを明らかにした (国内・国際学会発表、論文準備中)。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Causes of Carryover

29年度が最終年度であるため、記入しない。

Expenditure Plan for Carryover Budget

29年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University of Manchester/King's College of London(United Kingdom)
  • Country Name: United Kingdom
  • Counterpart Institution: University of Manchester/King's College of London
• [Int'l Joint Research] Johns Hopkins University/Cleveland Clinic Foundation/University of Wisconsin-Madison(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Johns Hopkins University/Cleveland Clinic Foundation/University of Wisconsin-Madison
• [Journal Article] てんかんの治療戦略：てんかん外科における言語機能温存へ向けた試み． (2018)
  • Author(s): 松本理器,下竹昭寛,山尾幸広,菊池隆幸,國枝武治．
  • Journal Title: 神経心理学 Volume: 印刷中 Pages: 印刷中
• [Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway. (2017)
  • Author(s): Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Human Brain Mapping. Volume: 38 Pages: 1977-1991
  • DOI: doi: 10.1002/hbm.23498
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms. (2017)
  • Author(s): Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R.
  • Journal Title: Neuroimage Volume: 15 Pages: 302-313
  • DOI: doi: 10.1016/j.neuroimage.
  • Peer Reviewed / Open Access
• [Journal Article] Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy (2017)
  • Author(s): Matsumoto R, Kunieda T, Nair D.
  • Journal Title: Seizure Volume: 44 Pages: 27-36
  • DOI: 10.1016/j.seizure.2016.11.003.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Frontal Fibers Connecting the Superior Frontal Gyrus to Broca Area: A Corticocortical Evoked Potential Study. (2017)
  • Author(s): Ookawa S, Enatsu R, Kanno A, Ochi S, Akiyama Y, Kobayashi T, Yamao Y, Kikuchi T, Matsumoto R, Kunieda T, Mikuni N
  • Journal Title: World Neurosurgery. Volume: 107 Pages: 239-248
  • DOI: 10.1016/j.wneu.2017.07.166.
  • Peer Reviewed
• [Journal Article] Phasic REM Transiently Approaches Wakefulness in the Human Cortex―A Single-Pulse Electrical Stimulation Study. (2017)
  • Author(s): Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A
  • Journal Title: Sleep. Volume: 40 Pages: -
  • DOI: 10.1093/sleep/zsx077.
  • Peer Reviewed
• [Journal Article] High frequency activity overriding cortico-cortical evoked potentials reflects altered excitability in the human epileptic focus. (2017)
  • Author(s): Kobayashi K, Matsumoto R, Matsuhashi M, Usami K, Shimotake A, Kunieda T, Kikuchi T, Yoshida K, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Clinical Neurophysiology. Volume: 128 Pages: 1673-1681
  • DOI: 10.1016/j.clinph.2017.06.249.
  • Peer Reviewed
• [Journal Article] We could predict good responders to vagus nerve stimulation: A surrogate marker by slow cortical potential shift. (2017)
  • Author(s): Bayasgalan B, Matsuhashi M, Fumuro T, Nohira H, Nakano N, Iida K, Katagiri M, Shimotake A, Matsumoto R, Kikuchi T, Kunieda T, Kato A, Takahashi R, Ikeda A
  • Journal Title: Clinical Neurophysiology Volume: 128 Pages: 1583-1589
  • DOI: 10.1016/j.clinph.2017.05.019
  • Peer Reviewed
• [Journal Article] CCEPのオフライン解析と解釈 特集「CCEPのskills workshop：clinical practice parameter（臨床実践指標）を目指して」 (2017)
  • Author(s): 小林 勝哉、松本 理器、松橋 眞生、中江 卓郎、宇佐美 清英、山尾 幸宏、菊池 隆幸、吉田 和道、國枝 武治、池田 昭夫
  • Journal Title: 臨床神経生理学 Volume: 45 Pages: 91-101
  • DOI: 10.11422/jscn.45.91
  • Peer Reviewed
• [Presentation] アンカーボルトを用いた定位的頭蓋内深部電極挿入術の初期経験－課題の抽出と挿入精度向上の検討－ (2018)
  • Author(s): 稲田拓, 菊池隆幸, 小林勝哉, 山尾幸広, 吉田和道, 國枝武治, 松本理器, 池田昭夫 and 宮本享
  • Organizer: 第 41 回日本てんかん外科学会
• [Presentation] Cortico-cortical evoked potentials & soectral responses to probe connectivity and cortical excitability. (2017)
  • Author(s): Matsumoto R
  • Organizer: 51st Annual Congress of the Japan Epilepsy Society
  • Invited
• [Presentation] Subdural recording in epilepsy. M08C: Clinical Neurophysiology. Invasive studies (2017)
  • Author(s): Matsumoto R, Kikuchi T, Yoshida K, Kunieda T, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research / Invited
• [Presentation] Neural basis of altered consciousness during sleep: insights from effective connectivity and induced high gamma activities (2017)
  • Author(s): Matsumoto R, Usami K, Kikuchi T, Yoshida K, Ikeda A
  • Organizer: Neural Oscillation Conference 2017
  • Int'l Joint Research / Invited
• [Presentation] Novel surrogate biomarkers of epileptogenicity using wideband ECoG analyses. (2017)
  • Author(s): Matsumoto R, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Ikeda A
  • Organizer: The 76th Annual Meeting of the Japan Neurosurgery Society
  • Invited
• [Presentation] Introduction. Dual stream model of language - its function, connectivity and plasticity: insights from clinical neuroscience (2017)
  • Author(s): Matsumoto R
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2017)
  • Invited
• [Presentation] てんかんの治療戦略：てんかん外科における言語機能温存へ向けた試み. シンポジウムII．高次脳機能障害の治療戦略． (2017)
  • Author(s): 松本理器，下竹昭寛，山尾幸広，菊池隆幸，國枝武治
  • Organizer: 第41回日本神経心理学会
  • Invited
• [Presentation] 皮質脳波と高次脳機能ネットワーク (2017)
  • Author(s): 松本理器、下竹昭寛，菊池隆幸，國枝武治、池田昭夫
  • Organizer: 第47回日本臨床神経生理学会
  • Invited
• [Presentation] Intractable Focal Epilepsy (2017)
  • Author(s): Ikeda A
  • Organizer: 10th International Epilepsy Colloquium
  • Int'l Joint Research / Invited
• [Presentation] EEG and electrophysiological monitoring (2017)
  • Author(s): Ikeda A
  • Organizer: 15th Advanced International Epilepsy Course: Bridging Basic with Clinical Epileptology-6
  • Int'l Joint Research / Invited
• [Presentation] What to do when nothing works Surgery and stimulation: Bridging Basic with Clinical Epileptology-6 (2017)
  • Author(s): Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research / Invited
• [Presentation] Safety of single-pulse electrical stimulation for cortico-cortical evoked potentials in epileptic human cerebral cortex (2017)
  • Author(s): Kobayashi K, Matsumoto R, Usami K, Matsuhashi M, Shimotake A, Nakae T, Takeyama H, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Compensatory semantic processing after resection of the anterior temporal lobe in epilepsy surgery (2017)
  • Author(s): Ota M, Shimotake A, Matsumoto R, Sakamoto M, Daifu M, Nakae T, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Matthew L.R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Efficacy of Wide-Band Electrocorticography(ECoG) on Mapping of the Primary Sensori-Motor Area Compared with Electrical Cortical Stimulation (ECS) (2017)
  • Author(s): Neshige S, Matsuhashi M, Sakurai T, Kobayashi K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Maruyama H, Takahashi R and Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Higher-order motor cortices actively engage in motor inhibition: cortical stimulation and event-related potentials as an evidence from subdural electrodes (2017)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Role of the negative motor area in praxis: A high frequency electrical cortical stimulation study (2017)
  • Author(s): Togo M, Matsumoto R, Shimotake A, Kobayashi T, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Functional gradient of the ventral temporal area in reading Kanji and Kana words. A quantitative low-intensity cortical stimulation study (2017)
  • Author(s): Daifu M, Matsumoto R, Shimotake A, Ota M, Sakamoto M, Nakae T, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Lambon Ralph M, Ikeda A
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] The human entorhinal cortex is connected with the broad neocortical regions through the hippocampalthalamo-cortical pathway possible as the memory network: Results from electrical tract tracing and neuropsychologicalassessment (2017)
  • Author(s): Takeyama H, Matsumoto R, Nakae T, Kobayashi K, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R Ikeda A
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Role of the anterior temporal lobe in the ventral pathway: evidence from presurgical evaluations in epilepsy patient" (2017)
  • Author(s): Shimotake A, Matsumoto R, Kikuchi R, Yoshida K, Kunieda R, Ikeda A.
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
  • Invited
• [Presentation] Active engagement of higher-order motor cortices in motor inhibition: Evidence fromdirect neural recording and stimulation during Go/No-Go paradigm (2017)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Functional connectivity from human superior parietal lobule and medial parietal lobe: A cortico-coritcal evoked potential (CCEP) study (2017)
  • Author(s): Togo M, Matsumoto R, Nakae T, Takeyama H, Kobayashi K, Shimotake A, Usami K, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Jeavonssyndrome can manifest paroxysmal alexia:acase report (2017)
  • Author(s): Yamada-Otani M, Matsumoto R, Shimotake A, Uehara N, Demura A, Kinoshita M, Takahashi R, Ikeda A.
  • Organizer: 第51回日本てんかん学会学術大会
• [Presentation] Functional brain mapping of higher-order motor cortices engaging in motor inhibition: A combined event-related potential and stimulation study (2017)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第51回日本てんかん学会学術大会
• [Presentation] Role of the Negative Motor Area in Praxis: A High Frequency Electrical Cortical Stimulation Study (2017)
  • Author(s): Togo M, Matsumoto R, Shimotake A, Kobayashi T, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第51回日本てんかん学会
• [Presentation] 難治部分てんかん患者での単発皮質電気刺激の発作誘発率に関する安全性：皮質皮質間誘発電位計測時の検討 (2017)
  • Author(s): 小林勝哉, 松本理器, 宇佐美清英, 松橋眞生, 下竹昭寛, 中江卓郎, 武山博文, 菊池隆幸, 吉田和道, 國枝武治, 高橋良輔 and 池田昭夫
  • Organizer: 第47回日本臨床神経生理学会学術大会
• [Presentation] アンカーボルトを用いた定位的頭蓋内深部電極挿入術の国内への本格導入に向けて－単一施設での導入経験－ (2017)
  • Author(s): 稲田拓, 菊池隆幸, 小林勝哉, 山尾幸広, 吉田和道, 國枝武治, 松本理器, 池田昭夫 and 宮本享
  • Organizer: 日本脳神経外科学会第 76 回学術総会
• [Presentation] 皮質皮質間誘発電位における非典型波形の検討 (2017)
  • Author(s): 迎伸孝, 松本理器, 小林勝哉, 十河正弥, 松橋眞生, 中江卓郎, 武山博文, 下竹昭寛, 山尾幸広, 菊池隆幸, 吉田和道, 飯原弘二, 髙橋良輔 and 池田昭夫
  • Organizer: 第47回日本臨床神経生理学会学術大会
• [Presentation] 質電気刺激による行為関連ネットワークマッピング (2017)
  • Author(s): 下竹昭寛,松本理器,小林勝哉,國枝武治,三國信啓,宮本亨,高橋良輔,池田昭夫
  • Organizer: 第47回日本臨床神経生理学会
• [Presentation] Sleep exerts a change in network effective connectivity. Causality analysis of human brain network evoked by single-pulse electrical stimulation (2017)
  • Author(s): Kiyohide Usami, Anna Korzeniewska, Riki Matsumoto, Kunieda Takeharu, Nobuhiro Mikuni, Katsuya Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda, and Nathan E. Crone
  • Organizer: Annual meeting of American Epilepsy Society Meeting 2017
  • Int'l Joint Research
• [Presentation] 術中言語白質モニタリングにおける皮質-皮質間誘発電位への麻酔の影響の検討 (2017)
  • Author(s): 山尾 幸広、松本 理器、國枝 武治、荒川 芳輝、中江 卓郎、菊池 隆幸、吉田 和道、池田 昭夫、宮本 享
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] Anesthetic effect on cortico-cortical evoked potentials during intraoperative dorsal language pathway monitoring (2017)
  • Author(s): 山尾 幸広、松本 理器、國枝 武治、荒川 芳輝、中江 卓郎、菊池 隆幸、吉田 和道、池田 昭夫、宮本 享
  • Organizer: Neuroscience 2017
• [Presentation] 皮質-皮質間誘発電位の機能的結合を基としたトラクトグラフィーでの一次運動野・一次感覚野間の機能的結合の同定 (2017)
  • Author(s): 山尾 幸広、松本 理器、國枝 武治、荒川 芳輝、菊池 隆幸、吉田 和道、池田 昭夫、Marco Catani, 宮本 享
  • Organizer: 日本脳神経外科学会 第76回 学術総会
• [Presentation] Fronto-parietal network in language-dominant hemisphere: an intraoperative CCEP (cortico-cortical evoked potential) study (2017)
  • Author(s): Nakae T, Matsumoto R, Arakawa Y, Inada R, Nishida S, Inada T, Takahashi Y, Kobayasi T, Kobayashi K, Yamao Y, Shimotake A, Kikuchi T, Aso T, Yoshida K, Kunieda T, Takahashi R, Ikeda A, Miyamoto S
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2017)
• [Book] Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy (2018)
  • Author(s): Matsumoto R, Kunieda T
  • Total Pages: 印刷中
  • Publisher: Oxford University Press (London)
  • ISBN: -
• [Book] ガイトン生理学 (2018)
  • Author(s): 十川純平、音成秀一郎、十河正弥、池田 昭夫
  • Total Pages: 1100
  • Publisher: エルセビア・ジャパン
  • ISBN: 978-4860347741
• [Book] Clinical Neuroscience 35 (2017)
  • Author(s): 中谷光良，小林勝哉，松本理器
  • Total Pages: 900
  • Publisher: 中外医学社
  • ISBN: -
• [Book] 臨床神経生理検査入門 (2017)
  • Author(s): 下竹昭寛、松本理器
  • Total Pages: 288
  • Publisher: 中山書店
  • ISBN: 978-4-521-74545-9
• [Remarks] 京都大学大学院医学研究科てんかん・運動異常生理学講座 研究紹介
  • URL: http://epilepsy.med.kyoto-u.ac.jp/research
• [Remarks] 京都大学大学院医学研究科臨床神経学 研究紹介
  • URL: http://www.kuhp.kyoto-u.ac.jp/~neurology/laboratory/lab_3_5.htm