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2018 Fiscal Year Final Research Report

Formation of Functional Molecules Based on Functional Alkyllithium Generations

Research Project

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Project/Area Number 26288049
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Synthetic chemistry
Research InstitutionKyoto University

Principal Investigator

NAGAKI AIICHIRO  京都大学, 工学研究科, 准教授 (80452275)

Project Period (FY) 2014-04-01 – 2019-03-31
Keywords炭素アニオン / フロー合成 / マイクロリアクター / アルキルリチウム / 不安定活性種
Outline of Final Research Achievements

Flow microreactors provide a powerful method for novel transformations via functional alkyllithiums that cannot be achieved using a conventional macro batch reactor. Various functional alkyllithiums involving electrophilic functional groups was successfully generated and used for subsequent reactions. The series of reactions with high reactivity could be achieved by extremely accurate control over residence time in a controlled and selective manner.

Free Research Field

マイクロ合成化学

Academic Significance and Societal Importance of the Research Achievements

フローマイクロリアクターの特長を活かし、「活性種制御法」や「反応の選択性制御法」を深化させ、sp3炭素アニオン活性種の高次制御を基軸とする機能性物質創製法のための本研究成果は、従来のフラスコでの合成化学の枠を超えて、今までにない分子変換プロセスや機能性物質創製法を提供するものである。

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Published: 2020-03-30  

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