2016 Fiscal Year Final Research Report
Critical role of newly identified S100A8/A9 receptors in lung specific cancer metastasis
| Project/Area Number |
26290039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡部 昌実 岡山大学, 大学病院, 教授 (70444677)
村田 等 岡山大学, 医歯(薬)学総合研究科, 講師 (90579096)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 炎症 / がん / 転移 / S100A8/A9 / S100A8/A9受容体 |
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| Outline of Final Research Achievements |
We succeeded to uncover that the functional receptors for S100A8/A9 were not restricted to RAGE and TLR4. Our advanced study showed that EMMPRIN also played a pivotal role in cancer metastasis in response to S100A8/A9. This discovery further spurred us to identify the unknown receptors, resulting in novel findings, NPTNa;, NPTNb;, MCAM and ALCAM receptors, we then named the collection of receptors “S100 Soil Sensor Receptors, shortly termed SSSRs” in our context of studies. We figured out that these novel receptors, especially EMMPRIN, NPTNb;, MCAM were cooperatively acting with each other at specific stages such as epithelial-methenchymal trandition (EMT), floating, adhesion, and invasion, and in the elaborate cancer metastatic processes. Our ongoing studies will help us to achieve better understanding of cancer behaviors and also the establishment of an innovative method for the prevention of cancer metastasis.
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| Free Research Field |
腫瘍生物学、分子細胞生物学
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