2017 Fiscal Year Final Research Report
Molecular mechanism regulating intracellular and organismal magnesium levels
| Project/Area Number |
26291042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
MIKI Hiroaki 大阪大学, 微生物病研究所, 教授 (80302602)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAZAKI Daisuke 大阪大学, 微生物病研究所, 准教授 (50422415)
FUNATO Yosuke 大阪大学, 微生物病研究所, 助教 (60505775)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | マグネシウム |
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| Outline of Final Research Achievements |
In this research project, I performed multiple analyses on CNNM Mg2+ transporter proteins, using mammalian cultured cells, mice, and nematodes. As a result, I elucidated that CNNM proteins play important roles in regulating intracellular Mg2+ levels and Mg2+ absorption in the intestine. Intracellular Mg2+ levels affected the energy status of cells, which had a significant impact on mTOR signaling. Moreover, I found that dysregulation of Mg2+ levels caused sperm malfunction and imbalance of proliferation/differentiation of intestinal epithelia.
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| Free Research Field |
細胞生物学
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