Analysis of molecular mechanism for initial left-right axis formation in the node of mouse embryos

2017 Fiscal Year Final Research Report

• Project/Area Number: 26291051
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Kyushu University
• Principal Investigator: Chikara Meno 九州大学, 医学研究院, 教授 (20311764)
• Co-Investigator(Renkei-kenkyūsha): OKI Shinya 九州大学, 医学研究院, 助教 (90452713) ; KITAJIMA Keiko 九州大学, 医学研究院, 助教 (00332784) ; OHKAWA Yasuyuki 九州大学, 生体防御医学研究所, 教授 (80448430)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 左右軸 / データベース / ChIP-seq

Outline of Final Research Achievements

The node appears in early mouse embryo and functions as a generator of left-right axis. Since this function depends on spatiotemporal information and interaction with adjacent tissues, associating the node with embryonic system is an important view to understand left-right axis formation. In this project, we analyzed the gene regulation by Nodal signal which is required for node and left-right axis formation, and also examined the expression mechanism for Wnt3a which is required for the expression on left-right axis related genes around the node. Additionally, we developed SraTailor and ChIP-Atlas which were utilized in above project. ChIP-Atlas is an integrated database by which proteins-DNA interactions based on all ChIP-seq data are displayed on IGV genome browser.

Free Research Field

発生生物学