2016 Fiscal Year Final Research Report
Analyses of chromatin interaction responsible for subnuclear dynamics
| Project/Area Number |
26291067
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Sakamoto Takuya 東京理科大学, 理工学部, 助教 (40637691)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | クロマチン / 核内構造 |
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| Outline of Final Research Achievements |
The purpose of this project is to reveal the dynamics of chromatin in nuclei. We successfully performed four-dimensional live-cell imaging using lacO/LacI inserted visualization lines. Based on this system, we could get dynamic data of chromatin-interaction in the nucleus of living cells. We identified a chromatin remodeling protein RAD54 as a regulator responsible for chromatin interaction and revealed a part of molecular mechanism in subnuclear chromatin dynamics.
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| Free Research Field |
生命動態学
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