2016 Fiscal Year Final Research Report
Genome anthropology study for testing the Cold adaptation and Anti-Obesity hypothesis in East Asia
| Project/Area Number |
26291096
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical anthropology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡邉 和寿 自治医科大学, 医学部, 助教 (60724416)
大橋 順 東京大学, 理学(系)研究科(研究院), 准教授 (80301141)
西村 貴孝 長崎大学, 医歯(薬)学総合研究科, 助教 (80713148)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | モンゴル人 / ゲノム多様性 / 寒冷適応 / 正の自然選択 / 肥満 |
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| Outline of Final Research Achievements |
Obesity in modern humans is caused by the imbalance between energy intake and expenditure. Metabolic thermogenesis is enhanced by various stimuli including cold exposure and partly explains the energy expenditure in the human body. We hypothesized that the susceptibility to obesity in the present human populations consists of genotypes that had contributed to adaptation to cold environments during modern human evolution. To demonstrate this hypothesis, we promoted a multidisciplinary study integrating evolutionary genetics at genome wide level, genetic epidemiology, and molecular cellular biology.
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| Free Research Field |
人類学
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