2016 Fiscal Year Final Research Report
Immunomodulation by foods based on elucidation of novel interactions of intestinal immune cells
| Project/Area Number |
26292065
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高橋 宜聖 国立感染症研究所, 免疫部, 室長 (60311403)
細野 朗 日本大学, 生物資源科学部, 教授 (70328706)
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| Research Collaborator |
ADACHI Haruyo 東京大学, 農学生命科学研究科, 特任助教 (20595962)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 食品 / 食品機能 / 食品免疫 / 腸管免疫 / 制御性T細胞 / 樹状細胞 / 乳酸菌 / 濾胞性T細胞 |
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| Outline of Final Research Achievements |
The purpose of this study was to elucidate novel interactions of intestinal immune cells to develop immunomodulating functional foods. We firstly examined the dendritic cell subset of mouse mesenteric lymph node with high regulatory T cell inducing function. Then, we examined the gene expression profiles of two regulatory T cell populations induced in oral tolerance by DNA microarray. Furthermore, the mechanism of induction of T follicular helper cells by lactic acid bacteria for food was examined in an in vitro culture with dendritic cells, T cells and B cells. Finally the responses of innate lymphoid cells of gut-associated lymphoid to intestinal bacteria were examined.
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| Free Research Field |
食品免疫学
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