2016 Fiscal Year Final Research Report
Search for lead-compounds for new antitumor drug development from alkaloids in medicinal plant reources
| Project/Area Number |
26293023
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Natural medicines
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
KITAJIMA Mariko 千葉大学, 大学院薬学研究院, 准教授 (60195261)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 天然活性物質 / 生物活性物質の探索 / 天然物 / 全合成 / 構造解析 / プロドラッグ |
|---|
| Outline of Final Research Achievements |
To develop highly tumor-selective colchicine derivatives, 4-chlorocolchicine-derived prodrug compound was designed and synthesized. Its cytotoxic activity toward human cancer cell lines was evaluated and the formation of nanoparticles was investigated. Asymmetric total syntheses of alkaloids including Kopsia and Gelsemium alkaloids were accomplished. Several indole alkaloids with novel structure were isolated from Kopsia plants. Vincamine-type alkaloids showed cytotoxic activity toward human cancer cell lines.
|
| Free Research Field |
天然物化学
|
