2016 Fiscal Year Final Research Report
Elucidation of the importance of novel transporters in the disposition of cationic drugs
| Project/Area Number |
26293032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 有機カチオン / トランスポーター / 薬物動態 / 血液脳関門 / 薬物輸送 / メタボローム解析 |
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| Outline of Final Research Achievements |
In order to elucidate the physiological functions of transporters expressing specifically in the blood brain barrier in the brain, in vitro transporter study, and in vivo pharmacokinetic and metabolome analysis in gene knockout mice were conducted. In addition to clarifying the substrate and inhibitor specificities of SLC35F2 in vitro screening using over expression system, changes in the concentrations of drugs and/or endogenous compounds in the brain and urine (urinary excretion) were observed in the knockout mice, suggesting that SLC35F2 is involved in the membrane transport of these compounds.
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| Free Research Field |
分子薬物動態学
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