2016 Fiscal Year Final Research Report
Regulatory mechanism of REM sleep by using manipulation of activity and fate of melanin concentrating hormone producinf neurons
| Project/Area Number |
26293046
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 睡眠覚醒 / 視床下部 / メラニン凝集ホルモン / 遺伝子改変 / 光遺伝学 / ノンレム睡眠 / レム睡眠 / 運命制御 |
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| Outline of Final Research Achievements |
Activity of MCH neurons were manipulated by optogenetics. Sleep/wakefulness analysis during manipulation of MCH neurons revealed its role in the regulation of sleep/wakefulness. Activation of MCH neurons increased total time in REM sleep to three-hold. However, time in wakefulness was not affected. These results suggest that MCH neurons play role in the regulation of sleep/wakefulness, especially in the transition of non-REM sleep and REM sleep.
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| Free Research Field |
神経生理学
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