Common mechanisms of synaptic plasticity underling olfactory bonds

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293047
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Kochi University
• Principal Investigator: KABA Hideto 高知大学, 医学部, 特任教授 (50136371)
• Co-Investigator(Kenkyū-buntansha): 奥谷 文乃 高知大学, 教育研究部医療学系看護学部門, 教授 (10194490) ; 谷口 睦男 高知大学, 教育研究部医療学系基礎医学部門, 准教授 (10304677) ; 村田 芳博 高知大学, 教育研究部医療学系基礎医学部門, 助教 (40377031)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 匂い / 記憶 / 学習 / 嗅球 / 長期増強 / アクチン重合化 / バゾプレッシン / 小胞体

Outline of Final Research Achievements

In this study we demonstrate (1) in a simple model, in which the ability of female mice to recognize their mate’s chemosignals ensures the maintenance of their pregnancy, actin polymerization is required for the late-phase of long-term potentiation (LTP) at the mitral-to-granule cell synapse in the accessory olfactory bulb, and vasopressin, acting at vasopressin receptor 1a, is also required for the induction of LTP and (2) the function of the endoplasmic reticulum is important for aversive olfactory learning and synaptic plasticity at the mitral-to-granule cell synapse in the olfactory bulb in neonatal rats.

Free Research Field

医歯薬学