2017 Fiscal Year Final Research Report
Roles of bioactive lipids in regulation of lymphatic plasticity
| Project/Area Number |
26293055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤田 朋恵 獨協医科大学, 医学部, 教授 (20296510)
天野 英樹 北里大学, 医学部, 講師 (60296481)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | prostaglandin / lymphatic / lymph node / edema / inflammation / metastasis / tumor |
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| Outline of Final Research Achievements |
The lymphatic system is an important route for cancer dissemination, and lymph node metastasis (LNM) serves as a critical prognostic determinant in cancer patients. COX-2 is expressed in DCs from the early stage in the lymph node subcapsular regions, and COX-2 inhibition markedly suppressed mediastinal LNM. LNM was reduced in mice lacking the PGE2 receptor EP3. Accumulation of Tregs was also COX-2/EP3-dependent. To clarify the roles of cyclooxygenase (COX)-2 in enhancement of lymphangiogenesis during secondary lymphedema, we tested a mouse tail model and evaluated the recurrence of lymph flow. Lymphangiogenesis, together with recurrence of lymph flow after surgical induction of lymphedema, is upregulated by COX-2 possibly via generation of PGs. Lymphangiogenesis plays an important role in wound-healing. Lymphangiogenesis and recruitment of M2 macrophages that produced VEGF-C/D were suppressed in mice treated with a COX-2 inhibitor or lacking either EP3 or EP4 during wound healing.
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| Free Research Field |
薬理学
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