2016 Fiscal Year Final Research Report
Analysis of Bach2-mediated regulation of the chronic allergic inflammation
| Project/Area Number |
26293069
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUWAHARA Makoto 愛媛大学, 大学院医学系研究科, 助教 (00568214)
TAMAUCHI Hidekazu 愛媛県立医療大学, 保健科学部, 教授 (60188414)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Bach2 / Batf / Th2 / Th2型気道炎症 |
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| Outline of Final Research Achievements |
The expression of Bach2, a transcriptional repressor, in CD4 T cells is reduced by antigenic stimulation. The decreased Bach2 expression is resulted in the onset of Th2-type allergic airway inflammation. However, molecular mechanism by which Bach2 regulates Th2-type airway inflammation. In this study, we found that Bach2 interacts with Batf family transcription factors and binds to the AP-1 consensus DNA motifs at the locus control region of the Th2 cytokine gene locus. Thus, Bach2-Batf complex inhibits Th2 cell differentiation and subsequent Th2-type airway inflammation.
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| Free Research Field |
免疫学
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