2016 Fiscal Year Final Research Report
Different roles of receptor activity modifying protein subtypes: ramp2 and ramp3 in development of colitis
| Project/Area Number |
26293085
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
新藤 隆行 信州大学, 学術研究院医学系, 教授 (90345215)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アドレノメデュリン / RAMP / 炎症性腸疾患 / ゲノム編集 / 発生工学 / 遺伝子改変動物 / 疾患モデル |
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| Outline of Final Research Achievements |
In this research project, we analyzed the pathophysiological role of ramp2, and ramp3 using dextran sodium sulfate (DSS) -induced colitis model of various gene modified mice. Both ramp2 and ramp3 have been implicated in the DSS-induced colitis. Furthermore, we demonstrated that development of colitis is augmented by ramp3, whereas ramp2 is protective against it. Our results provide novel insights into ramp signaling in colon.
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| Free Research Field |
発生工学、 発生生物学
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