2016 Fiscal Year Final Research Report
Differentiation of innate lymphoid cells
| Project/Area Number |
26293110
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
Kazuyo Moro 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (90468489)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Ikawa Tomokatsu 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (60450392)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | ILC2 / 分化 / ストローマ細胞 |
|---|
| Outline of Final Research Achievements |
In this project, we found that the concentration of IL-7 differentially regulates T cell and ILC2 differentiation. Furthermore, to clarify the microenvironment that supports ILC2 development, we identified ILC progenitors and immature ILC2 in the fetal mesentery. We also showed by transplantation analysis that mesentery functions as a site that induces differentiation of mature ILC2.
|
| Free Research Field |
自然リンパ球
|
