Construction of immunosurveillance system by symbiotic network in the Peyer's patches

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293111
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: National Institutes of Biomedical Innovation, Health and Nutrition
• Principal Investigator: KUNISAWA Jun 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチン・アジュバント研究センター, プロジェクトリーダー (80376615)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 共生細菌 / 炎症 / IgA抗体 / LPS

Outline of Final Research Achievements

The intestinal immune system is involved in the maintenance of immunological homeostasis in the gut. It is known that Peyer’s patches play a central role in regulating intestinal immunity, which is at least partly regulated by intestinal bacteria. In this study, we aim to clarify the function of Alcaligenes, a symbiotic bacteria found in Peyer's patches, in the regulation of intestinal immunity and found that Alcaligenes itself and Alcaligenes LPS possess unique features to moderately regulate intestinal immunity without induction of excessive inflammation.

Free Research Field

環境免疫学