2016 Fiscal Year Final Research Report
Elucidation of the genetic factors and the mechanisms of adverse effects by anti-rheumatic drugs.
| Project/Area Number |
26293123
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | University of Tsukuba (2015-2016)
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital (2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
當間 重人 独立行政法人国立病院機構(相模原病院臨床研究センター), リウマチ性疾患研究部, 部長 (50207528)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUCHIYA Naoyuki 筑波大学, 医学医療系, 教授 (60231437)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 遺伝子診断・治療 |
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| Outline of Final Research Achievements |
It was tried to detect the genetic factors and the mechanisms of adverse effects by anti-rheumatic drugs. The genome wide association study was performed, but the results were not confirmed by the replication analysis. No specific micro RNA was detected in the plasma from the rheumatoid arthritis patients with methotrexate-induced interstitial lung diseases. The transgenic mouse of HLA-A*31:01, a susceptibility allele for methotrexate-induced interstitial lung diseases, was not more susceptible for the model of methotrexate-induced induced interstitial lung disease.
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| Free Research Field |
医歯薬学
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